Osteoarthritis Year in Review 2014: we need more biochemical biomarkers in qualification phase

被引：36

作者：

Blanco, Francisco J. ^{[1
]}

机构：

[1] Univ Coruna UDC, CHUAC, Inst Invest Biomed A Coruna INIBIC, ISCIII Serv Reumatol,Grp Prote ProteoRed PBR2, As Xubias 15006, A Coruna, Spain

来源：

OSTEOARTHRITIS AND CARTILAGE | 2014年 / 22卷 / 12期

关键词：

Osteoarthritis; Biomarker; Biological marker; Proteomics; Lipidomics; Metabolomics; KNEE OSTEOARTHRITIS; HAND OSTEOARTHRITIS; PROTEOMIC ANALYSIS; BONE BIOMARKERS; SYNOVIAL-FLUID; II COLLAGEN; SERUM; CARTILAGE; ASSOCIATIONS; INFLAMMATION;

D O I：

10.1016/j.joca.2014.09.009

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

100224 [整形外科学];

摘要：

The current diagnosis of osteoarthritis (OA) relies on the description of pain symptoms, affected joint stiffness, and radiography used as the reference technique for determining the grade of joint destruction. Limitations of the presently available diagnostic tests have provided an impetus for the substantial increase in interest in finding new specific biological markers for cartilage degradation to facilitate the early diagnosis of joint destruction, evaluate disease progression and improve disease prognosis. Biomarkers for OA are also useful for drug development, treatment monitoring, and as a basis for personalized evidence-based action plans. This review summarizes 29 manuscripts published during 2013 with a focus on soluble biochemical biomarkers, primarily those utilizing proteomic, metabolomics, lipidomic and imaging mass spectrometry technologies. (C) 2014 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

引用

页码：2025 / 2032

页数：8

共 29 条

[1]

Associations Between Biomarkers of Joint Metabolism, Hand Osteoarthritis, and Hand Pain and Function: The Johnston County Osteoarthritis Project [J].

Aslam, Imran ;

Perjar, Irina ;

Shi, Xiaoyan A. ;

Renner, Jordan B. ;

Kraus, Virginia B. ;

Golightly, Yvonne M. ;

Jordan, Joanne M. ;

Nelson, Amanda E. .

JOURNAL OF RHEUMATOLOGY, 2014, 41 (05) :938-944

[2]

Proteomic analysis of human osteoarthritis synovial fluid [J].

Balakrishnan, Lavanya ;

Nirujogi, Raja Sekhar ;

Ahmad, Sartaj ;

Bhattacharjee, Mitali ;

Manda, Srikanth S. ;

Renuse, Santosh ;

Kelkar, Dhanashree S. ;

Subbannayya, Yashwanth ;

Raju, Rajesh ;

Goel, Renu ;

Thomas, Joji Kurian ;

Kaur, Navjyot ;

Dhillon, Mukesh ;

Tankala, Shantal Gupta ;

Jois, Ramesh ;

Vasdev, Vivek ;

Ramachandra, Y. L. ;

Sahasrabuddhe, Nandini A. ;

Prasad, T. S. Keshava ;

Mohan, Sujatha ;

Gowda, Harsha ;

Shankar, Subramanian ;

Pandey, Akhilesh .

CLINICAL PROTEOMICS, 2014, 11

[3]

Association between cartilage and bone biomarkers and incidence of radiographic knee osteoarthritis (RKOA) in UK females: a prospective study [J].

Blumenfeld, O. ;

Williams, F. M. K. ;

Hart, D. J. ;

Spector, T. D. ;

Arden, N. ;

Livshits, G. .

OSTEOARTHRITIS AND CARTILAGE, 2013, 21 (07) :923-929

[4]

Metabolic health in families enriched for longevity is associated with low prevalence of hand osteoarthritis and influences OA biomarker profiles [J].

Bos, Steffan Daniel ;

Beekman, Marian ;

Maier, Andrea B. ;

Karsdal, Morton A. ;

Kwok, Wing-Yee ;

Bay-Jensen, Anne Christine ;

Kloppenburg, Margreet ;

Slagboom, P. Eline ;

Meulenbelt, Ingrid .

ANNALS OF THE RHEUMATIC DISEASES, 2013, 72 (10) :1669-1674

[5]

SPECIFIC PEPTIDE DISTRIBUTION IN HUMAN OSTEOARTHRITIC SYNOVIAL MEMBRANES REVEALS DIFFERENT GRADES OF TISSUE INFLAMMATION [J].

Cillero-Pastor, B. ;

Eijkel, G. ;

Blanco, F. ;

Heeren, R. .

OSTEOARTHRITIS AND CARTILAGE, 2014, 22 :S48-S49

[6]

LIPIDS AS MEDIATORS OF CHONDROGENESIS [J].

Georgi, N. ;

Pastor, B. Cillero ;

Eijkel, G. ;

Periyasamy, P. C. ;

Kiss, A. ;

van Blitterswijk, C. ;

Post, J. N. ;

Heeren, R. ;

Karperien, M. .

OSTEOARTHRITIS AND CARTILAGE, 2014, 22 :S46-S48

[7]

Quantitation OF ARGS aggrecan fragments in synovial fluid, serum and urine from osteoarthritis patients [J].

Germaschewski, F. M. ;

Matheny, C. J. ;

Larkin, J. ;

Liu, F. ;

Thomas, L. R. ;

Saunders, J. S. ;

Sully, K. ;

Whittall, C. ;

Boyle, Y. ;

Peters, G. ;

Graham, N. M. .

OSTEOARTHRITIS AND CARTILAGE, 2014, 22 (05) :690-697

[8]

Metabolic Profiling Reveals Differences in Concentrations of Oxylipins and Fatty Acids Secreted by the Infrapatellar Fat Pad of Donors With End-Stage Osteoarthritis and Normal Donors [J].

Gierman, L. M. ;

Wopereis, S. ;

van El, B. ;

Verheij, E. R. ;

Werff-van der Vat, B. J. C. ;

Bastiaansen-Jenniskens, Y. M. ;

van Osch, G. J. V. M. ;

Kloppenburg, M. ;

Stojanovic-Susulic, V. ;

Huizinga, T. W. J. ;

Zuurmond, A. -M. .

ARTHRITIS AND RHEUMATISM, 2013, 65 (10) :2606-2614

[9]

BLOOD SERUM TO DIAGNOSE OSTEOARTHRITIS - BIOMARKERS AND MACHINE LEARNING [J].

Heard, B. J. ;

Rosvold, J. M. ;

Fritzler, M. J. ;

El-Gabalawy, H. ;

Wiley, J. P. ;

Krawetz, R. J. .

OSTEOARTHRITIS AND CARTILAGE, 2014, 22 :S64-S64

[10]

Early decrease of serum biomarkers of type II collagen degradation (Coll2-1) and joint inflammation (Coll2-1 NO2) by hyaluronic acid intra-articular injections in patients with knee osteoarthritis: A research study part of the Biovisco study [J].

Henrotin, Y. ;

Chevalier, X. ;

Deberg, M. ;

Balblanc, J. C. ;

Richette, P. ;

Mulleman, D. ;

Maillet, B. ;

Rannou, F. ;

Piroth, C. ;

Mathieu, P. ;

Conrozier, T. .

JOURNAL OF ORTHOPAEDIC RESEARCH, 2013, 31 (06) :901-907

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