Cerebral inflammation and degeneration in systemic lupus erythematosus

被引：39

作者：

Trysberg, E ^{[1
]}

Tarkowski, A ^{[1
]}

机构：

[1] Gothenburg Univ, Sahlgrens Univ Hosp, Dept Rheumatol & Inflammat Res, S-41346 Gothenburg, Sweden

来源：

CURRENT OPINION IN RHEUMATOLOGY | 2004年 / 16卷 / 05期

关键词：

systemic lupus erythematosus; central nervous system; cytokines; metalloproteinases; astroglial fibrillary acidic protein; neurofilament; amyloid protein; Tau; MRI; cerebrospinal fluid; neuropsychological examinations;

D O I：

10.1097/01.bor.0000135451.85671.14

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Purpose of review This review deals with new information related to central nervous system lupus, with special emphasis on mechanisms engaged in inflammation and neurodegeneration. Recent findings We report the very recent findings related to neuropsychiatric lupus in areas of (1) neuroimaging, (2) immunology and genetics, (3) biochemistry, and (4) neuropsychological tests. The relation between treatment of central nervous system lupus and immunologic/biochemical parameters as an outcome variable is also reported. Summary The recent advances in the field of neuropsychiatric lupus allow better understanding of the pathogenesis of the disease and follow-up of disease activity during immunosuppressive treatment.

引用

页码：527 / 533

页数：7

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