Paxillin: Adapting to change

被引：517

作者：

Brown, MC ^{[1
]}

Turner, CE ^{[1
]}

机构：

[1] SUNY Upstate Med Univ, Dept Cell & Dev Biol, Syracuse, NY 13210 USA

来源：

PHYSIOLOGICAL REVIEWS | 2004年 / 84卷 / 04期

关键词：

D O I：

10.1152/physrev.00002.2004

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Molecular scaffold or adaptor proteins facilitate precise spatiotemporal regulation and integration of multiple signaling pathways to effect the optimal cellular response to changes in the immediate environment. Paxillin is a multidomain adaptor that recruits both structural and signaling molecules to focal adhesions, sites of integrin engagement with the extracellular matrix, where it performs a critical role in transducing adhesion and growth factor signals to elicit changes in cell migration and gene expression.

引用

页码：1315 / 1339

页数：25

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