Ulinastatin attenuates lung ischemia-reperfusion injury in rats by inhibiting tumor necrosis factor alpha

被引：88

作者：

Ren, B. ^{[1
]}

Wu, H. ^{[1
]}

Zhu, J. ^{[1
]}

Li, D. ^{[1
]}

Shen, Y. ^{[1
]}

Ying, R. ^{[1
]}

Dong, G. ^{[1
]}

Jing, H. ^{[1
]}

机构：

[1] Nanjing Univ, Jinling Hosp, Sch Clin Med, Dept Thorac & Cardiovasc Surg, Nanjing, jiangsu, Peoples R China

来源：

TRANSPLANTATION PROCEEDINGS | 2006年 / 38卷 / 09期

关键词：

D O I：

10.1016/j.transproceed.2006.08.166

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Ischemia-reperfusion (I/R) injury may influence graft function following transplantation. Ulinastatin, a urinary trypsin inhibitor has been shown to attenuate I/R injury in various organs such as intestine, heart, and kidney in animals. The present experiment was designed to evaluate the effect of pretreatment with ulinastatin on I/R-induced lung injury. Methods. After establishing a constant left lung warm ischemia-reperfusion model in rats, 45 animals were randomly divided into three experimental groups: sham group (11 15), IR group (n = 15), and ulinastatin (5000 U/kg pre-ischemia) + IR group (11 = 15). The lung injury was evaluated by tissue myeloperoxidase activity, with simultaneous estimation of the serum concentration of TNF alpha. Results. The ulinastatin-pretreated animals exhibited markedly decreased lung tissue myeloperoxidase activity (P <.05). Blood gas analysis demonstrated, that the treated animals had significantly ameliorated pulmonary oxygenation (P <.05). The serum concentration of TNF-alpha in the ulinastatin-pretreated group was markedly decreased compared with that of the I/R group (P <.05). Conclusions. Ulinastatin attenuated I/R-induced lung injury. This function is partly related to the capacity of the agent to inhibit myeoloperoxidase activity in lung tissue and decrease systemic expression to TNF-alpha.

引用

页码：2777 / 2779

页数：3

共 8 条

[1]

FR167653 ameliorates pulmonary damage in ischemia-reperfusion injury in a canine lung transplantation model [J].