Human immunoglobulin ameliorates rat experimental autoimmune neuritis

被引：41

作者：

Gabriel, CM

Gregson, NA

Redford, EJ

Davies, M

Smith, KJ

Hughes, RAC

机构：

[1] Department of Neurology, UMDS, Guy's Hospital, London

[2] Department of Neurology, Medical School, UMDS Guy's Hospital, London SE1 9RT, London Bridge

来源：

BRAIN | 1997年 / 120卷

关键词：

experimental autoimmune neuritis; immunoglobulin; IVIg; polyneuropathy; demyelination;

D O I：

10.1093/brain/120.9.1533

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Human immunoglobulin is an effective treatment for Guillain-Barre syndrome, although the mechanism of action is not understood. We have investigated the effect of human immunoglobulin in an animal model of Guillain-Barre syndrome, namely experimental autoimmune neuritis (EAN), induced in Lewis rats by immunization with bovine spinal root myelin. Human immunoglobulin administered intraperitoneally at the time of onset of disease accelerated the rate of recovery from EAN. This improvement was associated with a reduction in the titre of anti-rat myelin antibodies and may be due to earlier remyelination of demyelinated nerve fibres. This model may facilitate further investigation of the mechanism of therapeutic action of immunoglobulin in inflammatory neuropathy.

引用

页码：1533 / 1540

页数：8

共 31 条

[1] INTRAVENOUS IMMUNOGLOBULIN TREATMENT OF EXPERIMENTAL T-CELL-MEDIATED AUTOIMMUNE-DISEASE - UP-REGULATION OF T-CELL PROLIFERATION AND DOWN-REGULATION OF TUMOR-NECROSIS-FACTOR-ALPHA SECRETION [J].