Two modes of activity-dependent synaptogenesis of cerebral neurons in vitro

被引：8

作者：

Kiyosue, K

Kasai, M

Taguchi, T

机构：

[1] OSAKA NATL RES INST,DEPT ORGAN MAT,IKEDA,KUMAMOTO 563,JAPAN

[2] OSAKA UNIV,FAC ENGN SCI,DEPT BIOPHYS ENGN,TOYONAKA,OSAKA 560,JAPAN

来源：

NEUROREPORT | 1996年 / 7卷 / 03期

关键词：

synaptogenesis; neurone; culture; EPSCs; glutamatergic; synapse; transmitter release;

D O I：

10.1097/00001756-199602290-00005

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

EFFECTs of transduction activity and transmission activity on synaptogenesis of chick cerebral neurones in dissociated cell culture were studied electrophysiologically using two blockers for these activities, tetrodotoxin (TTX) and 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), respectively. CNQX inhibited the increase of evoked EPSCs more effectively than TTX, whereas both blockers similarly reduced the increase of miniature EPSCs (Minis). These data indicated that not only transduction-dependent transmission activity but also transduction-independent spontaneous activity regulate the synaptic efficiency. These two activities are suggested to change the quantal amplitude and the number of synaptic sites, respectively.

引用

页码：701 / 704

页数：4

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