BDNF atelocollagen mini-pellet accelerates facial nerve regeneration

被引：26

作者：

Kohmura, E

Yuguchi, T

Yoshimine, T

Fujinaka, T

Koseki, N

Sano, A

Kishino, A

Nakayama, C

Sakaki, T

Nonaka, M

Takemoto, O

Hayakawa, T

机构：

[1] Osaka Univ, Grad Sch Med, Dept Neurosurg, Suita, Osaka 5650871, Japan

[2] Sumitomo Pharmaceut Co Ltd, Formulat Res Labs, Osaka, Japan

[3] Sumitomo Pharmaceut Co Ltd, Neurosci Res Grp, Osaka, Japan

来源：

BRAIN RESEARCH | 1999年 / 849卷 / 1-2期

关键词：

GAP-43; BDNF; facial nerve; regeneration; in situ hybridization; drug delivery system;

D O I：

10.1016/S0006-8993(99)02163-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We investigated the effect of BDNF mini-pellet on the GAP-43 mRNA expression and functional status of facial nerve in a rat model of facial nerve transection and immediate repair. The facial function started to recover at 17 days in the placebo group and 14 days in the BDNF group. BDNF group had shorter period of increased GAP-43 mRNA expression than the placebo group. Topically applied BDNF may accelerate the facial nerve regeneration. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：235 / 238

页数：4

共 17 条

[1] PRIMARY STRUCTURE AND TRANSCRIPTIONAL REGULATION OF GAP-43, A PROTEIN ASSOCIATED WITH NERVE GROWTH [J].