Binding of inferred germline precursors of broadly neutralizing HIV-1 antibodies to native-like envelope trimers

被引：37

作者：

Sliepen, Kwinten ^{[1
]}

Medina-Ramirez, Max ^{[1
]}

Yasmeen, Anila ^{[2
]}

Moore, John P. ^{[2
]}

Klasse, Per Johan ^{[2
]}

Sanders, Rogier W. ^{[1
,2
]}

机构：

[1] Univ Amsterdam, Acad Med Ctr, Dept Med Microbiol, NL-1105 AZ Amsterdam, Netherlands

[2] Cornell Univ, Weill Med Coll, Dept Microbiol & Immunol, New York, NY 10065 USA

来源：

VIROLOGY | 2015年 / 486卷

基金：

欧洲研究理事会;

关键词：

Broadly neutralizing antibodies; Germline; HIV-1; Env; SOSIP; Vaccine; CONFORMATIONAL EPITOPE; IMMUNOGEN DESIGN; VACCINE; QUATERNARY; LINEAGE; CLADE;

D O I：

10.1016/j.virol.2015.08.002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

HIV-1 envelope glycoproteins (Env) and Env-based immunogens usually do not interact efficiently with the inferred germline precursors of known broadly neutralizing antibodies (bNAbs). This deficiency may be one reason why Env and Env-based immunogens are not efficient at inducing bNAbs. We evaluated the binding of 15 inferred germline precursors of bNAbs directed to different epitope clusters to three soluble native-like SOSIP.664 Env trimers. We found that native-like SOSIP.664 trimers bind to some inferred germline precursors of bNAbs, particularly ones involving the V1/V2 loops at the apex of the trimer. The data imply that native-like SOSIP.664 trimers will be an appropriate platform for structure-guided design improvements intended to create immunogens able to target the germline precursors of bNAbs. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：116 / 120

页数：5

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