Cytotoxicity of cyanoacrylate adhesives to cultured tendon cells

被引：25

作者：

Evans, CE ^{[1
]}

Lees, GC ^{[1
]}

Trail, IA ^{[1
]}

机构：

[1] Univ Manchester, Dept Orthopaed Surg, Manchester M13 9PL, Lancs, England

来源：

JOURNAL OF HAND SURGERY-BRITISH AND EUROPEAN VOLUME | 1999年 / 24B卷 / 06期

关键词：

D O I：

10.1054/jhsb.1999.0279

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

The in vitro cytotoxicity of four cyanoacrylate adhesives,vas tested using cultures of cells derived from human tendons. All four mere found to be cytotoxic, even at concentrations as low as 1.7%, over the experimental period of up to 18 weeks, This study shows that such adhesives in their present state may not be suitable for re-joining cut tendons as their initial and long-term toxicity may hinder the slow healing process of tendons.

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页码：658 / 661

页数：4

相关论文

共 14 条

[1]

EFFECT OF ESTERASE ON METHACRYLATES AND METHACRYLATE POLYMERS IN AN ENZYME SIMULATOR FOR BIODURABILITY AND BIOCOMPATIBILITY TESTING [J].

BEAN, TA ;

ZHUANG, WC ;

TONG, PY ;

EICK, JD ;

YOURTEE, DM .

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 1994, 28 (01) :59-63

[2]

Characterization of a fibrin glue-GDNF slow-release preparation [J].

Cheng, HR ;

Fraidakis, M ;

Blomback, B ;

Lapchak, P ;

Hoffer, B ;

Olson, L .

CELL TRANSPLANTATION, 1998, 7 (01) :53-61

[3]

TOXICITY OF CYANOACRYLATES IN-VITRO USING EXTRACT DILUTION ASSAY ON CELL-CULTURES [J].

CIAPETTI, G ;

STEA, S ;

CENNI, E ;

SUDANESE, A ;

MARRARO, D ;

TONI, A ;

PIZZOFERRATO, A .

BIOMATERIALS, 1994, 15 (02) :92-96

[4]

Fibroblast-like cells from tendons differ from skin fibroblasts in their ability to form three-dimensional structures in vitro [J].

Evans, CE ;

Trail, IA .

JOURNAL OF HAND SURGERY-BRITISH AND EUROPEAN VOLUME, 1998, 23B (05) :633-641

[5]

Contact sensitization to cyanoacrylate adhesive as a cause of severe onychodystrophy [J].

Guin, JD ;

Baas, K ;

Nelson-Adesokan, P .

INTERNATIONAL JOURNAL OF DERMATOLOGY, 1998, 37 (01) :31-36

[6]

HACHIDA M, 1987, J THORAC CARDIOV SUR, V93, P344

[7]

HODGSON SP, 1993, THESIS U MANCHESTER

[8]

RAPID COLORIMETRIC ASSAY FOR CELLULAR GROWTH AND SURVIVAL - APPLICATION TO PROLIFERATION AND CYTO-TOXICITY ASSAYS [J].

MOSMANN, T .

JOURNAL OF IMMUNOLOGICAL METHODS, 1983, 65 (1-2) :55-63

[9]

Noordzij J. Pieter, 1994, Journal of Emergency Medicine, V12, P645

[10]

NEUROPATHOLOGICAL CHANGES RELATED TO THE TRANSORBITAL APPLICATION OF ETHYL 2-CYANOACRYLATE ADHESIVE TO THE BASAL CEREBRAL-ARTERIES OF CATS [J].

SMITH, TW ;

DEGIROLAMI, U ;

CROWELL, RM .

JOURNAL OF NEUROSURGERY, 1985, 62 (01) :108-114