Studies of the effects of vilon and epithalon on gene expression in mouse heart using DNA-microarray technology

被引：10

作者：

Anisimov, SV

Bokheler, KR

Khavinson, VK

Anisimov, VN

机构：

[1] Russian Acad Med Sci, St Petersburg Inst Bioregulat & Gerontol, Northwestern Div, St Petersburg, Russia

[2] NIA, Baltimore, MD 21224 USA

[3] Minist Publ Hlth Russia, NN Petrov Inst Oncol, St Petersburg, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2002年 / 133卷 / 03期

关键词：

gene expression; DNA-microarray; peptides; Vilon; epithalon;

D O I：

10.1023/A:1015859322630

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Expression of 15,247 clones from a cDNA library in the heart of mice receiving Vilon and Epithalon was studied by DNA-microarray technology. We revealed 300 clones (1.94% of the total count), whose expression changed more than by 2 times. Vilon changed expression of 36 clones, while Epithalon modulated expression of 98 clones. Combined treatment with Vilon and Epithalon changed expression of 144 clones. Vilon alone or in combination with Epithalon activated expression of 157 clones (maximally by 6.13 times) and inhibited expression of 23 clones (maximally by 2.79 times). Epithalon alone or in combination with Vilon activated expression of 194 clones (maximally by 6.61 times) and inhibited expression of 48 clones (maximally by 2.71 times). Our results demonstrate the specific effects of Epithalon and Vilon on gene expression.

引用

页码：293 / 299

页数：7

共 15 条

[1]

ANISIMOV AN, 1995, ACTA GERONTOL, V45, P137

[2] 20 YEARS OF STUDY ON EFFECTS OF PINEAL PEPTIDE PREPARATION - EPITHALAMIN IN EXPERIMENTAL GERONTOLOGY AND ONCOLOGY [J].