A mechanical basis for chromosome function

被引：240

作者：

Kleckner, N

Zickler, D

Jones, GH

Dekker, J

Padmore, R

Henle, J

Hutchinson, J

机构：

[1] Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA

[2] Univ Paris 11, Genet Lab, Inst Genet & Microbiol, Ctr Orsay, F-91405 Orsay, France

[3] Univ Birmingham, Sch Biosci, Birmingham B15 2TT, W Midlands, England

[4] Univ Massachusetts, Sch Med, Program Gene Funct & Express, Worcester, MA 01605 USA

[5] Univ Massachusetts, Sch Med, Dept Mol Pharmacol & Biochem, Worcester, MA 01605 USA

[6] Harvard Univ, Dept Engn & Appl Sci, Cambridge, MA 02138 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2004年 / 101卷 / 34期

关键词：

D O I：

10.1073/pnas.0402724101

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We propose that chromosome function is governed by internal mechanical forces generated by programmed tendencies for expansion of the DNA/chromatin fiber against constraining features.

引用

页码：12592 / 12597

页数：6

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