Human in vivo radiation-induced biomarkers:: Gene expression changes in radiotherapy patients

被引：195

作者：

Amundson, SA

Grace, MB

McLeland, CB

Epperly, MW

Yeager, A

Zhan, QM

Greenberger, JS

Fornace, AJ

机构：

[1] NIH, Ctr Canc Res, NCI, Bethesda, MD USA

[2] Armed Forces Radiobiol Res Inst, Biol Dosimetry Team, Bethesda, MD USA

[3] Univ Pittsburgh, Inst Canc, Pittsburgh, PA USA

来源：

CANCER RESEARCH | 2004年 / 64卷 / 18期

关键词：

D O I：

10.1158/0008-5472.CAN-04-1883

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

After initially identifying potential biomarkers of radiation exposure through microarray studies of ex vivo irradiated human peripheral white blood cells, we have now measured the in vivo responses of several of these biomarker genes in patients undergoing total body irradiation. Microarray analysis has identified additional in vivo radiation-responsive genes, although the general in vivo patterns of stress-gene induction appear similar to those obtained from ex vivo white blood cell experiments. Additional studies may reveal correlations between responses and either diagnosis or prognosis, and such in vivo validation marks an important step in the development of potentially informative radiation exposure biomarkers.

引用

页码：6368 / 6371

页数：4

共 16 条

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