Predictive Factors of Response to Biological Disease Modifying Antirheumatic Drugs: Towards Personalized Medicine

被引：52

作者：

Daien, Claire I. ^{[1
]}

Morel, Jacques

机构：

[1] Univ Montpellier I II, Lapeyronie Hosp, Dept Rheumatol, Route Mende, F-34295 Montpellier 5, France

来源：

MEDIATORS OF INFLAMMATION | 2014年 / 2014卷

关键词：

TUMOR-NECROSIS-FACTOR; RHEUMATOID-ARTHRITIS PATIENTS; ANTI-TNF THERAPY; CLINICAL-RESPONSE; BRITISH-SOCIETY; RADIOGRAPHIC PROGRESSION; CITRULLINATED PEPTIDE; ADALIMUMAB TREATMENT; INFLIXIMAB THERAPY; CIGARETTE-SMOKING;

D O I：

10.1155/2014/386148

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Many therapies are now available for patients with rheumatoid arthritis (RA) who have an inadequate response to methotrexate including tumor necrosis factor inhibitors, abatacept, tocilizumab, and rituximab. Clinical response to drugs varies widely between individuals. A part of this variability is due to the characteristics of the patient such as age, gender, concomitant therapies, body mass index, or smoking status. Clinical response also depends on disease characteristics including disease activity and severity and presence of autoantibodies. Genetic background, cytokine levels, and immune cell phenotypes could also influence biological therapy response. This review summarizes the impact of all those parameters on response to biological therapies.

引用

页数：11

共 62 条

[1]

Anti-TNF-α Agents Are Less Effective for the Treatment of Rheumatoid Arthritis in Current Smokers [J].

Abhishek, A. ;

Butt, S. ;

Gadsby, K. ;

Zhang, W. ;

Deighton, C. M. .

JCR-JOURNAL OF CLINICAL RHEUMATOLOGY, 2010, 16 (01) :15-18

[2]

Influence of gender on assessments of disease activity and function in early rheumatoid arthritis in relation to radiographic joint damage [J].

Ahlmen, M. ;

Svensson, B. ;

Albertsson, K. ;

Forslind, K. ;

Hafstrom, I. .

ANNALS OF THE RHEUMATIC DISEASES, 2010, 69 (01) :230-233

[3]

Clinical response to adalimumab: relationship to anti-adalimumab antibodies and serum adalimumab concentrations in rheumatoid arthritis [J].

Bartelds, Geertje M. ;

Wijbrandts, Carla A. ;

Nurmohamed, Michael T. ;

Stapel, Steven ;

Lems, Willem F. ;

Aarden, Lucien ;

Dijkmans, Ben A. C. ;

Tak, Paul Peter ;

Wolbink, Gerrit Jan .

ANNALS OF THE RHEUMATIC DISEASES, 2007, 66 (07) :921-926

[4]

Clinical remission and/or minimal disease activity in patients receiving adalimumab treatment in a multinational, open-label, twelve-week study [J].

Burmester, Gerd R. ;

Ferraccioli, Gianfranco ;

Flipo, Rene-Marc ;

Monteagudo-Saez, Indalecio ;

Unnebrink, Kristina ;

Kary, Sonia ;

Kupper, Hartmut .

ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH, 2008, 59 (01) :32-41

[5]

Comparative effectiveness and predictors of response to tumour necrosis factor inhibitor therapies in rheumatoid arthritis [J].

Canhao, Helena ;

Rodrigues, Ana Maria ;

Mourao, Ana Filipa ;

Martins, Fernando ;

Santos, Maria Jose ;

Canas-Silva, Jose ;

Polido-Pereira, Joaquim ;

Pereira Silva, Jose Alberto ;

Costa, Jose Antonio ;

Araujo, Domingos ;

Silva, Candida ;

Santos, Helena ;

Duarte, Catia ;

Pereira da Silva, Jose Antonio ;

Pimentel-Santos, Fernando M. ;

Branco, Jaime Cunha ;

Karlson, Elizabeth W. ;

Fonseca, Joao Eurico ;

Solomon, Daniel H. .

RHEUMATOLOGY, 2012, 51 (11) :2020-2026

[6]

Therapeutic activity of humanized anti-CD20 monoclonal antibody and polymorphism in IgG Fc receptor FcγRIIIa gene [J].

Cartron, G ;

Dacheux, L ;

Salles, G ;

Solal-Celigny, P ;

Bardos, P ;

Colombat, P ;

Watier, H .

BLOOD, 2002, 99 (03) :754-758

[7]

Highest clinical effectiveness of rituximab in autoantibody-positive patients with rheumatoid arthritis and in those for whom no more than one previous TNF antagonist has failed: pooled data from 10 European registries [J].

Chatzidionysiou, Katerina ;

Lie, Elisabeth ;

Nasonov, Evgeny ;

Lukina, Galina ;

Hetland, Merete Lund ;

Tarp, Ulrik ;

Gabay, Cem ;

van Riel, Piet L. C. M. ;

Nordstrom, Dan C. ;

Gomez-Reino, Juan ;

Pavelka, Karel ;

Tomsic, Matija ;

Kvien, Tore K. ;

van Vollenhoven, Ronald F. .

ANNALS OF THE RHEUMATIC DISEASES, 2011, 70 (09) :1575-1580

[8]

Increasing levels of circulating Th17 cells and interleukin-17 in rheumatoid arthritis patients with an inadequate response to anti-TNF-α therapy [J].

Chen, Der-Yuan ;

Chen, Yi-Ming ;

Chen, Hsin-Hua ;

Hsieh, Chia-Wei ;

Lin, Chi-Chen ;

Lan, Joung-Liang .

ARTHRITIS RESEARCH & THERAPY, 2011, 13 (04)

[9]

Rheumatoid Arthritis Risk Allele PTPRC Is Also Associated With Response to Anti-Tumor Necrosis Factor α Therapy [J].

Cui, Jing ;

Saevarsdottir, Saedis ;

Thomson, Brian ;

Padyukov, Leonid ;

van der Helm-van Mil, Annette H. M. ;

Nititham, Joanne ;

Hughes, Laura B. ;

de Vries, Niek ;

Raychaudhuri, Soumya ;

Alfredsson, Lars ;

Askling, Johan ;

Wedren, Sara ;

Ding, Bo ;

Guiducci, Candace ;

Wolbink, Gert Jan ;

Crusius, J. Bart A. ;

van der Horst-Bruinsma, Irene E. ;

Herenius, Marieke ;

Weinblatt, Michael E. ;

Shadick, Nancy A. ;

Worthington, Jane ;

Batliwalla, Franak ;

Kern, Marlena ;

Morgan, Ann W. ;

Wilson, Anthony G. ;

Isaacs, John D. ;

Hyrich, Kimme ;

Seldin, Michael F. ;

Moreland, Larry W. ;

Behrens, Timothy W. ;

Allaart, Cornelia F. ;

Criswell, Lindsey A. ;

Huizinga, Tom W. J. ;

Tak, Paul P. ;

Bridges, S. Louis, Jr. ;

Toes, Rene E. M. ;

Barton, Anne ;

Klareskog, Lars ;

Gregersen, Peter K. ;

Karlson, Elizabeth W. ;

Plenge, Robert M. .

ARTHRITIS AND RHEUMATISM, 2010, 62 (07) :1849-1861

[10]

Etanercept Concentration in Patients with Rheumatoid Arthritis and Its Potential Influence on Treatment Decisions: A Pilot Study [J].

Daien, Claire Immediato ;

Daien, Vincent ;

Parussini, Ermis ;

Dupuy, Anne-Marie ;

Combe, Bernard ;

Morel, Jacques .

JOURNAL OF RHEUMATOLOGY, 2012, 39 (08) :1533-1538

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