Expression analysis of 21 transcripts physically anchored within the chromosomal region 10q24

被引：7

作者：

Nobile, C ^{[1
]}

Pitzalis, S ^{[1
]}

机构：

[1] Ist Genet Mol, I-07041 Alghero, Italy

来源：

GENOMICS | 1999年 / 62卷 / 01期

关键词：

D O I：

10.1006/geno.1999.5988

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Chromosome band 10q24 harbors the critical regions for inherited neurological disorders such as partial epilepsy (EPT), urofacial syndrome, and a distinct form of spastic paraparesis. To facilitate the selection of candidate genes for these diseases, we determined the mRNA sizes and analyzed the expression patterns of 21 brain transcripts defined by expressed sequence tags previously localized along a 7.4-Mb interval of 10q24. In addition to a number of widely expressed transcribed sequences, we identified several transcripts exclusively or predominantly expressed in the brain, which represent potential candidates for the neurological diseases associated with this genomic region. (C) 1999 Academic Press.

引用

页码：86 / 89

页数：4

共 11 条

[1] DBEST - DATABASE FOR EXPRESSED SEQUENCE TAGS [J].

BOGUSKI, MS ;

LOWE, TMJ ;

TOLSTOSHEV, CM .

NATURE GENETICS, 1993, 4 (04) :332-333

[2] A novel gene, LGI1, from 10q24 is rearranged and downregulated in malignant brain tumors [J].

Chernova, OB ;

Somerville, RPT ;

Cowell, JK .

ONCOGENE, 1998, 17 (22) :2873-2881

[3] A physical map of 30,000 human genes [J].

Deloukas, P ;

Schuler, GD ;

Gyapay, G ;

Beasley, EM ;

Soderlund, C ;

Rodriguez-Tomé, P ;

Hui, L ;

Matise, TC ;

McKusick, KB ;

Beckmann, JS ;

Bentolila, S ;

Bihoreau, MT ;

Birren, BB ;

Browne, J ;

Butler, A ;

Castle, AB ;

Chiannilkulchai, N ;

Clee, C ;

Day, PJR ;

Dehejia, A ;

Dibling, T ;

Drouot, N ;

Duprat, S ;

Fizames, C ;

Fox, S ;

Gelling, S ;

Green, L ;

Harrison, P ;

Hocking, R ;

Holloway, E ;

Hunt, S ;

Keil, S ;

Lijnzaad, P ;

Louis-Dit-Sully, C ;

Ma, J ;

Mendis, A ;

Miller, J ;

Morissette, J ;

Muselet, D ;

Nusbaum, HC ;

Peck, A ;

Rozen, S ;

Simon, D ;

Slonim, DK ;

Staples, R ;

Stein, LD ;

Stewart, EA ;

Suchard, MA ;

Thangarajah, T ;

Vega-Czarny, N .

SCIENCE, 1998, 282 (5389) :744-746

[4] An integrated physical and genetic map spanning chromosome band 10q24 [J].

Gray, IC ;

Fallowfield, J ;

Ford, S ;

Nobile, C ;

Volpi, EV ;

Spurr, NK .

GENOMICS, 1997, 43 (01) :85-88

[5] Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening [J].

Nakayama, M ;

Nakajima, D ;

Nagase, T ;

Nomura, N ;

Seki, N ;

Ohara, O .

GENOMICS, 1998, 51 (01) :27-34

[6] A refined physical and EST map spanning 7.4 Mb of 10q24, a region involved in neurological disorders [J].

Nobile, C ;

Manca, A ;

Pisano, M ;

Angius, A ;

Gray, IC ;

Spurr, NK .

MAMMALIAN GENOME, 1998, 9 (10) :835-837

[7]

OTTMAN R, 1995, NAT GENET, V10, P55

[8] SLIT - AN EXTRACELLULAR PROTEIN NECESSARY FOR DEVELOPMENT OF MIDLINE GLIA AND COMMISSURAL AXON PATHWAYS CONTAINS BOTH EGF AND LRR DOMAINS [J].

ROTHBERG, JM ;

JACOBS, JR ;

GOODMAN, CS ;

ARTAVANISTSAKONAS, S .

GENES & DEVELOPMENT, 1990, 4 (12A) :2169-2187

[9] A gene map of the human genome [J].

Schuler, GD ;

Boguski, MS ;

Stewart, EA ;

Stein, LD ;

Gyapay, G ;

Rice, K ;

White, RE ;

RodriguezTome, P ;

Aggarwal, A ;

Bajorek, E ;

Bentolila, S ;

Birren, BB ;

Butler, A ;

Castle, AB ;

Chiannilkulchai, N ;

Chu, A ;

Clee, C ;

Cowles, S ;

Day, PJR ;

Dibling, T ;

Drouot, N ;

Dunham, I ;

Duprat, S ;

East, C ;

Edwards, C ;

Fan, JB ;

Fang, N ;

Fizames, C ;

Garrett, C ;

Green, L ;

Hadley, D ;

Harris, M ;

Harrison, P ;

Brady, S ;

Hicks, A ;

Holloway, E ;

Hui, L ;

Hussain, S ;

LouisDitSully, C ;

Ma, J ;

MacGilvery, A ;

Mader, C ;

Maratukulam, A ;

Matise, TC ;

McKusick, KB ;

Morissette, J ;

Mungall, A ;

Muselet, D ;

Nusbaum, HC ;

Page, DC .

SCIENCE, 1996, 274 (5287) :540-546

[10] Genetic mapping to 10q23.3-q24.2, in a large Italian pedigree, of a new syndrome showing bilateral cataracts, gastroesophageal reflux, and spastic paraparesis with amyotrophy [J].

Seri, M ;

Cusano, R ;

Forabosco, P ;

Cinti, R ;

Caroli, F ;

Picco, P ;

Bini, R ;

Morra, VB ;

De Michele, G ;

Lerone, M ;

Silengo, M ;

Pela, I ;

Borrone, C ;

Romeo, G ;

Devoto, M .

AMERICAN JOURNAL OF HUMAN GENETICS, 1999, 64 (02) :586-593

← 1 2 →