PPAR-γ agonist pioglitazone affects rat gouty arthritis by regulating cytokines

被引：26

作者：

Wang, R. -C. ^{[1
]}

Jiang, D. -M. ^{[1
]}

机构：

[1] Chongqing Med Univ, Affiliated Hosp 1, Dept Orthoped, Chongqing, Peoples R China

来源：

GENETICS AND MOLECULAR RESEARCH | 2014年 / 13卷 / 03期

关键词：

Peroxisome proliferator-activated receptor; Interleukin; Tumor necrosis factor-alpha; Rats; ACTIVATED RECEPTOR-GAMMA; LIGAND;

D O I：

10.4238/2014.August.28.2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The objective was to study peroxisome proliferator-activated receptor gamma (PPAR.) agonist pioglitazone regulation effect and its mechanism of expression of cytokines on acute gouty arthritis synovial in rats. Rats with unilateral ankle were injected with artificial monosodium urate (MSU) crystals to make the acute gouty arthritis model. Taking the synovium 48 h after the injection of MSU and using RT-PCR, we assessed the effect of pioglitazone (20 mg.kg(-1).day(-1), oral administration) on synovial expression, by detecting tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta), and interferon-gamma (IFN-gamma). The pioglitazone treatment group showed synovial expression of TNF-alpha, and IFN-gamma was significantly lower than in the control group; the inhibition rates were 78.5 and 60.4%. The IL-1 expression difference was not statistically significant between the two groups. Pioglitazone has anti-inflammatory effects on acute gouty arthritis by inhibiting the expression of TNF-alpha and IFN-gamma.

引用

页码：6577 / 6581

页数：5

共 12 条

[1]

Treatment of active psoriatic arthritis with the PPARγ ligand pioglitazone:: an open-label pilot study [J].

Bongartz, T ;

Coras, B ;

Vogt, T ;

Schölmerich, J ;

Müller-Ladner, U .

RHEUMATOLOGY, 2005, 44 (01) :126-129

[2]

Reduction in the evolution of murine type II collagen-induced arthritis by treatment with rosiglitazone, a ligand of the peroxisome proliferator-activated receptor γ [J].

Cuzzocrea, S ;

Mazzon, E ;

Dugo, L ;

Patel, NSA ;

Serraino, I ;

Di Paola, R ;

Genovese, T ;

Britti, D ;

De Maio, M ;

Caputi, AP ;

Thiemermann, C .

ARTHRITIS AND RHEUMATISM, 2003, 48 (12) :3544-3556

[3]

Fam AG, 2002, J RHEUMATOL, V29, P1350

[4]

Finnegan A, 1999, J IMMUNOL, V163, P5383

[5]

Huang HG, 2005, MILIT MED SCI, V29, P538

[6]

[黄火高 HUANG Huogao], 2005, [中华风湿病学杂志, Chinese Journal of Rheumatology], V9, P463

[7]

[黄火高 HUANG Huogao], 2007, [天津医药, Tianjin Medical Journal], V35, P124

[8]

Pioglitazone, a peroxisome proliferator-activated receptor-γ agonist, reduces the progression of experimental osteoarthritis in guinea pigs [J].

Kobayashi, T ;

Notoya, K ;

Naito, T ;

Unno, S ;

Nakamura, A ;

Martel-Pelletier, J ;

Pelletier, JP .

ARTHRITIS AND RHEUMATISM, 2005, 52 (02) :479-487

[9]

Kushnarenko N N, 2012, Klin Lab Diagn, P17

[10]

Peroxisome proliferator-activated receptor γ agonists -: Potential use for treating chronic inflammatory diseases [J].

Oates, JC ;

Reilly, CM ;

Crosby, MB ;

Gilkeson, GS .

ARTHRITIS AND RHEUMATISM, 2002, 46 (03) :598-605

← 1 2 →