Vascular endothelial growth factor receptor-3 mediates induction of corneal alloimmunity

被引：174

作者：

Chen, L

Hamrah, P

Cursiefen, C

Zhang, Q

Pytowski, B

Streilein, JW

Dana, MR

机构：

[1] Schepens Eye Res Inst, Immunol Lab, Boston, MA 02114 USA

[2] Massachusetts Eye & Ear Infirm, Boston, MA 02114 USA

[3] Harvard Univ, Sch Med, Dept Ophthalmol, Boston, MA USA

[4] ImClone Syst, New York, NY USA

来源：

NATURE MEDICINE | 2004年 / 10卷 / 08期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nm1078

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

There are no studies so far linking molecular regulation of lymphangiogenesis and induction of adaptive immunity. Here, we show that blockade of vascular endothelial growth factor receptor-3 (VEGFR-3) signaling significantly suppresses corneal antigen-presenting ( dendritic) cell trafficking to draining lymph nodes, induction of delayed-type hypersensitivity and rejection of corneal transplants. Regulating the function of VEGFR-3 may therefore be a mechanism for modulating adaptive immunity in the periphery.

引用

收藏

页码：813 / 815

页数：4

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