Both integrated and differential regulation of components of the IL-2/IL-2 receptor system

被引：250

作者：

Kim, Hyoung Pyo ^{[1
]}

Imbert, Jean

Leonard, Warren J.

机构：

[1] NHLBI, Lab Mol Immunol, Ctr Immunol, NIH, Bethesda, MD 20892 USA

[2] Univ Mediterranee, Inst J Paoli I Calmettes, INSERM, UMR599,Ctr Rech Cancerol Marseille, F-13009 Marseille, France

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2006年 / 17卷 / 05期

关键词：

IL-2; receptor; transcription; gamma c; XSCID;

D O I：

10.1016/j.cytogfr.2006.07.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Interleukin-2 was discovered in 1976 as a T-cell growth factor. It was the first type I cytokine cloned and the first for which a receptor component was cloned. Its importance includes its multiple actions, therapeutic potential, and lessons for receptor biology, with three components differentially combining to form high, intermediate, and low-affinity receptors. IL-21ka and IL-2R beta, respectively, are markers for double-negative thymocytes and regulatory T-cells versus memory cells. gamma(c) which is shared by six cytokines, is mutated in patients with X-linked severe-combined immunodeficiency. We now cover an under-reviewed area-the regulation of genes encoding IL-2 and lL-2R components, with an effort to integrate/explain this knowledge. Published by Elsevier Ltd.

引用

页码：349 / 366

页数：18

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