The CD5+B-cell

被引：61

作者：

Dono, M

Cerruti, G

Zupo, S

机构：

[1] IST, Inst Nazl Ric Cancro, SC Oncol Med C, I-16132 Genoa, Italy

[2] Osp S Andrea, Lab Anal Chim Clin & Microbiol, La Spezia, Italy

[3] IST, SS Diagnost Malattia Linfoproliferativa, Genoa, Italy

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2004年 / 36卷 / 11期

关键词：

CD5+B-cells; autoantibodies; mantle cell lymphoma; B-cell chronic lymphocytic leukemia;

D O I：

10.1016/j.biocel.2004.05.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the last two decades, many efforts have been made to better understand the biology of B-lymphoproliferative disorders through the knowledge of physiology and function of the postulated normal counterpart. The follicular mantle B-cells express a typical CD23+ IgM+ IgD+ phenotype and surround the germinal center area in secondary lymphoid organs. CD5+ B-cells with FM phenotype can be isolated from different sources and all share similar morphologic, phenotypic and functional features (small cells, scanty nucleus/cytoplasm ratio, unmutated VH genes, response to polyclonal activators but not to T independent antigens, production of "natural" antibodies). While the CD5+ B-cells predominate in fetal life, their number decreases with age. However, the CD5+ B-cells have been demonstrated to increase again in elderly both in man and mouse. This finding may explain the incidence of B-CLL and of MCL that are believed to represent the malignant transformation of the normal CD5+ B-cells, among elderly and middle aged individuals, respectively. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：2105 / 2111

页数：7

共 23 条

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