The effect of kyphoscoliosis on intervertebral disc degeneration in dogs

被引：29

作者：

Faller, Kiterie ^{[1
]}

Penderis, Jacques ^{[1
]}

Stalin, Catherine ^{[1
]}

Guevar, Julien ^{[1
]}

Yeamans, Carmen ^{[1
]}

Gutierrez-Quintana, Rodrigo ^{[1
]}

机构：

[1] Univ Glasgow, Coll Med Vet & Life Sci, Sch Vet Med, Glasgow G61 1QH, Lanark, Scotland

来源：

VETERINARY JOURNAL | 2014年 / 200卷 / 03期

关键词：

Congenital Vertebral Malformation; Intervertebral Disc Degeneration; Kyphoscoliosis; Kyphosis; Scoliosis; HEMIVERTEBRA;

D O I：

10.1016/j.tvjl.2014.03.027

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

090604 [动物药学];

摘要：

In people, abnormalities in vertebral column conformation, such as kyphoscoliosis, induce degenerative changes in adjacent intervertebral disc (IVD) structure and composition. It was hypothesised that canine IVDs adjacent to a vertebral malformation undergo early degeneration. In a blinded retrospective study, thoracic IVD degeneration was evaluated in 14 dogs on magnetic resonance images using Pfirrmann's grade. IVDs adjacent to a vertebral malformation had higher grades of degeneration than non-adjacent IVDs (P < 0.0001). There was an age-dependency, with dogs between 1 and 4 years showing higher grade of degeneration in adjacent than non-adjacent IVDs (P < 0.0001). Conversely, in older dogs, all IVDs - including the non-adjacents - showed degenerative signs, possibly due to normal aging. These results suggest that congenital vertebral malformation results in early degeneration of adjacent IVDs. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：449 / 451

页数：3

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