PEGylated antibodies and antibody fragments for improved therapy: a review

被引：427

作者：

Chapman, AP ^{[1
]}

机构：

[1] Celltech R&D Ltd, BioProc Res, Slough SL1 4EN, Berks, England

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2002年 / 54卷 / 04期

关键词：

poly(ethylene glycol); monoclonal antibody; Fab'; single chain antibodies; antibody fragment; pharmacokinetics;

D O I：

10.1016/S0169-409X(02)00026-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The use of covalent attachment of poly(ethylene glycol) to various different proteins in order to modify their function has been reported over many years. One class of protein that this technology has more recently been applied to is antibodies and antibody fragments. PEG has been predominantly used to reduce the immunogenicity and increase the circulating half-lives of antibodies. It may also have a beneficial effect on the use of antibodies in certain clinical settings such as tumour targeting. This review describes previously reported experience with PEGylated antibodies and antibody fragments, and where these types of molecules may find clinical usefulness in the future. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：531 / 545

页数：15

共 39 条

[1] POLYMER MODIFICATION OF ANTIBODY TO ELIMINATE IMMUNE-COMPLEX AND FC BINDING [J].

ANDERSON, WL ;

TOMASI, TB .

JOURNAL OF IMMUNOLOGICAL METHODS, 1988, 109 (01) :37-42

[2]

Casey JL, 1999, TUMOR TARGET, V4, P235

[3] Therapeutic antibody fragments with prolonged in vivo half-lives [J].

Chapman, AP ;

Antoniw, P ;

Spitali, M ;

West, S ;

Stephens, S ;

King, DJ .

NATURE BIOTECHNOLOGY, 1999, 17 (08) :780-783

[4]

CO MS, 1993, MOL IMMUNOL, V30, P1361

[5] BIOLOGICAL-ACTIVITIES OF POLYETHYLENE-GLYCOL IMMUNOGLOBULIN CONJUGATES - RESISTANCE TO ENZYMATIC DEGRADATION [J].

CUNNINGHAMRUNDLES, C ;

ZHUO, Z ;

GRIFFITH, B ;

KEENAN, J .

JOURNAL OF IMMUNOLOGICAL METHODS, 1992, 152 (02) :177-190

[6]

Deckert PM, 2000, INT J CANCER, V87, P382, DOI 10.1002/1097-0215(20000801)87:3<382::AID-IJC12>3.3.CO

[7]

2-G

[8] Enhanced tumour specificity of an anti-carcinoembrionic antigen Fab' fragment by poly(ethylene glycol) (PEG) modification [J].

Delgado, C ;

Pedley, RB ;

Herraez, A ;

Boden, R ;

Boden, JA ;

Keep, PA ;

Chester, KA ;

Fisher, D ;

Begent, RHJ ;

Francis, GE .

BRITISH JOURNAL OF CANCER, 1996, 73 (02) :175-182

[9]

DELGADO C, 1994, METHOD ENZYMOL, V228, P395

[10] THE BINDING-SITE FOR CLQ ON IGG [J].

DUNCAN, AR ;

WINTER, G .

NATURE, 1988, 332 (6166) :738-740

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