p53: The barrier to cancer stem cell formation

被引：111

作者：

Aloni-Grinstein, Ronit ^{[1
]}

Shetzer, Yoav ^{[1
]}

Kaufman, Tom ^{[1
]}

Rotter, Varda ^{[1
]}

机构：

[1] Weizmann Inst Sci, Dept Mol Cell Biol, IL-76100 Rehovot, Israel

来源：

FEBS LETTERS | 2014年 / 588卷 / 16期

关键词：

Stem cells; p53; Loss of heterozygosity; Cancer stem cells; Tumorigenesis; TUMOR-SUPPRESSOR PATHWAY; SELF-RENEWING DIVISIONS; ACUTE MYELOID-LEUKEMIA; STEM/PROGENITOR CELLS; INDUCED PLURIPOTENCY; GENETIC ALTERATIONS; TARGETING NOTCH; SOMATIC-CELLS; DNA-DAMAGE; DIFFERENTIATION;

D O I：

10.1016/j.febslet.2014.02.011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The role of p53 as the "guardian of the genome" in differentiated somatic cells, triggering various biological processes, is well established. Recent studies in the stem cell field have highlighted a profound role of p53 in stem cell biology as well. These studies, combined with basic data obtained 20 years ago, provide insight into how p53 governs the quantity and quality of various stem cells, ensuring a sufficient repertoire of normal stem cells to enable proper development, tissue regeneration and a cancer free life. In this review we address the role of p53 in genomically stable embryonic stem cells, a unique predisposed cancer stem cell model and adult stem cells, its role in the generation of induced pluripotent stem cells, as well as its role as the barrier to cancer stem cell formation. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：2580 / 2589

页数：10

共 151 条

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