Brain myo-inositol level is elevated in Ts65Dn mouse and reduced after lithium treatment

被引：27

作者：

Huang, W ^{[1
]}

Galdzicki, Z

van Gelderen, P

Balbo, A

Chikhale, EG

Schapiro, MB

Rapoport, SI

机构：

[1] NIA, Neurosci Lab, Bethesda, MD 20892 USA

[2] NINDS, In Vivo NMR Res Ctr, Bethesda, MD 20892 USA

[3] SUNY Stony Brook, Dept Radiol, Stony Brook, NY 11794 USA

来源：

NEUROREPORT | 2000年 / 11卷 / 03期

关键词：

Down syndrome; lithium; magnetic resonance spectroscopy; myo-inositol; N-acetylaspartate; Ts65Dn;

D O I：

10.1097/00001756-200002280-00004

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The segmental trisomy Ts65Dn mouse is a novel model of Down syndrome (DS). The purpose of this study was to measure brain levels of myo-inositol (mI), N-acetylaspartate (NAA), and other metabolites in Ts65Dn mice using in vivo H-1 magnetic resonance spectroscopy (MRS), and to determine whether lithium (Li) treatment alters brain mI level. The ratio of mi over total creatine (Cr), ml/Cr, was significantly elevated (mean change +38%), while NAA/Cr was significantly decreased (mean change -18%) in Ts65Dn mice (n = 5) compared with control mice (n = 7). This is consistent with H-1 MRS findings in DS human adults. Brain ml/Cr of the entire sample group (n = 12) was reduced (mean change -15%) following Li treatment, supporting the Li-induced ml depletion hypothesis. NeuroReport 11:445-448 (C) 2000 Lippincott Williams & Wilkins.

引用

页码：445 / 448

页数：4

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