New advances in synthesis and clinical aspects of pyrazolo[3,4-d]pyrimidine scaffolds

被引：54

作者：

Abdellatif, Khaled R. A. ^{[1
,2
]}

Bakr, Rania B. ^{[1
,3
]}

机构：

[1] Beni Suef Univ, Fac Pharm, Dept Pharmaceut Organ Chem, Bani Suwayf 62514, Egypt

[2] Ibn Sina Natl Coll Med Studies, Pharmaceut Sci Dept, Jeddah 21418, Saudi Arabia

[3] Jouf Univ, Coll Pharm, Dept Pharmaceut Chem, Sakaka 2014, Al Jouf, Saudi Arabia

来源：

BIOORGANIC CHEMISTRY | 2018年 / 78卷

关键词：

Pyrazolo[3,4-d]pyrimidine; Anti-inflammatory; Anticancer agents; Antimicrobial; ONE-POT SYNTHESIS; ANTIMICROBIAL ACTIVITY; BIOLOGICAL EVALUATION; PYRIMIDINE-DERIVATIVES; ANTICANCER ACTIVITY; ANTITUMOR-ACTIVITY; KINASE INHIBITORS; CARCINOMA-CELLS; DESIGN; PYRAZOLES;

D O I：

10.1016/j.bioorg.2018.03.032

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Pyrazolo[3,4-d]pyrimidine ring system constitute an important class of heterocyclic compounds which can serve as a promising scaffold exhibiting many pharmacological activities. This ring system received much attention as it is a purine isostere by replacing imidazole ring in purine with pyrazole moiety in pyrazolo[3,4-d]pyrimidine. Here we concentrate on new advances in the synthesis of this important ring and other clinical aspects in an attempt to sheld the light to assist in discovery of new pyrazolo[3,4-d] pyrimidine derivatives. (C) 2018 Elsevier Inc. All rights reserved.

引用

页码：341 / 357

页数：17

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