An open study of tacrolimus therapy in Rasmussen encephalitis

被引：67

作者：

Bien, CG

Gleissner, U

Sassen, R

Widman, G

Urbach, H

Elger, CE

机构：

[1] Univ Bonn, Dept Epileptol, D-53105 Bonn, Germany

[2] Univ Bonn, Dept Radiol Neuroradiol, D-53105 Bonn, Germany

来源：

NEUROLOGY | 2004年 / 62卷 / 11期

关键词：

D O I：

10.1212/01.WNL.0000128044.94294.87

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Seven patients with Rasmussen encephalitis ( RE) were treated with the immunosuppressant tacrolimus and followed for a median of 22.4 months. They were compared with 12 historical untreated RE patients (median follow-up 13.9 months). The tacrolimus-treated patients had a superior outcome regarding neurologic function and progression rate of cerebral hemiatrophy but no better seizure outcome. No treated patient, but 7 of 12 control patients, became eligible for hemispherectomy. Tacrolimus did not have any major side effects.

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页码：2106 / 2109

页数：4

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