Design and synthesis of (E)-1-((3-ethyl-2,4,4-trimethylcyclohex-2-enylidene)methyl-4-substituted benzenes from 1-(2,6,6-trimethylcyclohex-1-enyl)ethanol

被引：11

作者：

Das, Bhaskar C. ^{[1
,2
]}

Mahalingam, Sakkarapalayam M. ^{[1
]}

Evans, Todd ^{[1
,3
]}

Kabalka, George W. ^{[4
,5
]}

Anguiano, J. ^{[1
]}

Hema, K. ^{[1
]}

机构：

[1] Albert Einstein Coll Med, Dept Dev & Mol Biol, Bronx, NY 10461 USA

[2] Albert Einstein Coll Med, Dept Nucl Med, Bronx, NY 10461 USA

[3] Weill Cornell Med Coll, Dept Surg, New York, NY 10065 USA

[4] Univ Knoxville, Dept Chem, Tennessee, TN USA

[5] Univ Knoxville, Dept Radiol, Tennessee, TN USA

来源：

CHEMICAL COMMUNICATIONS | 2009年 / 16期

关键词：

CROSS-COUPLING REACTIONS; ORGANOBORON COMPOUNDS; DERIVATIVES; RETINOIDS;

D O I：

10.1039/b823063c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel strategy for synthesizing (E)-1-((3-ethyl-2,4,4-trimethylcyclohex-2-enylidene)methyl-4-substituted benzenes from 1-(2,6,6-trimethylcyclohex-1-enyl)ethanol 3 has been developed; the allylic alcohol 3 was treated with PPh3 center dot HBr in methanol followed by aldehydes in the presence of a base and furnished the 1,3-dienes in moderate to good yields (79-86%).

引用

页码：2133 / 2135

页数：3

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