Synthesis of enantiomerically pure α-ethyl, α-vinyl and α-ethynyl 3,3,3-trifluoro alaninates

被引：38

作者：

Crucianelli, M

De Angelis, F

Lazzaro, F

Malpezzi, L

Volonterio, A

Zanda, M

机构：

[1] CNR, Ist Chim Riconoscimento Mol, Sez A Quilico, I-20131 Milan, Italy

[2] Univ Aquila, Dipartimento Chim Ingn Chim & Mat, I-67010 Coppito, Italy

[3] Politecn Milan, Dipartimento Chim Mat & Ingn Chim G Natta, I-20131 Milan, Italy

来源：

JOURNAL OF FLUORINE CHEMISTRY | 2004年 / 125卷 / 04期

关键词：

trifluoromethyl; alpha-amino acids; sulfinimine; stereoselective;

D O I：

10.1016/j.jfluchem.2003.11.034

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

We describe the first synthesis of enantiomerically pure (S)-alpha-vinyl and (S)-alpha-ethynyl 3,3,3-trifluoro alanine (TF-Ala) ethyl esters, starting from the in situ generated sulfinimine (S)-2 as key fluorinated building-block. (S)-alpha-Ethyl TF-Ala-OEt has been prepared as well by this route. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：573 / 577

页数：5

共 13 条

[1] SIR97:: a new tool for crystal structure determination and refinement [J].