Age, body mass index, current smoking history, and serum insulin-like growth factor-I levels associated with bone mineral density in middle-aged Korean men

被引:49
作者
Rhee, EJ
Oh, KW [1 ]
Lee, WY
Kim, SW
Oh, ES
Baek, KH
Kang, MI
Park, CY
Choi, MG
Yoo, HJ
Park, SW
机构
[1] Hallym Univ, Dept Internal Med, Anyang, South Korea
[2] Sungkyunkwan Univ, Sch Med, Dept Internal Med, Seoul, South Korea
[3] Miz Medi Hosp, Dept Internal Med, Seoul, South Korea
[4] Catholic Univ Korea, Coll Med, Dept Internal Med, Seoul, South Korea
关键词
age; body mass index; smoking; insulin-like growth factor-I; bone mineral density; men;
D O I
10.1007/s00774-003-0500-0
中图分类号
R5 [内科学];
学科分类号
1002 [临床医学]; 100201 [内科学];
摘要
Osteoporosis is a growing health problem in women and in men. This cross-sectional study examined the association of anthropometric, lifestyle, and hormonal factors with bone mineral density (BMD) in 152 healthy Korean middle-aged men. Smoking habits and alcohol consumption were assessed by interview. Serum testosterone and insulin-like growth factor-I (IGF-I) levels were measured by radioimmunoassay, and serum growth hormone (GH) levels were measured by immunoradiometric assay. GH stimulation tests were performed after the ingestion of 500 mg of L-dopa. BMD was measured at the lumbar spine and at the femoral neck by dual-energy X-ray absorptiometry. Of the middle-aged men, 3.9% were osteoporotic and 28.3% were osteopenic at the lumbar spine site, and 5.9% were osteoporotic and 45.4% were osteopenic at the femoral neck site. Lumbar spine BMD correlated significantly with body mass index (BMI), and femoral neck BMD correlated significantly with age, BMI, and serum IGF-I levels. The lowest quartile group for serum IGF-I levels showed the lowest femoral neck BMD. Osteoporotic men by lumbar spine BMD showed significant differences from the normal BMD group in terms of BMI and smoking habits. Also, osteoporotic men by femoral neck BMD were significantly different for mean age, BMI, and serum IGF-I levels compared with the normal BMD group. On multiple regression analysis, BMI was found to be the only independent predictor of lumbar spine BMD, whereas both BMI and serum IGF-I levels were found to be the independent predictors of femoral neck BMD. Overall, 28.3%-45.4% of middle-aged Korean men were osteopenic. We suggest that higher age, a lower BMI, current smoking history, and lower serum IGF-I levels are risk factors for lower BMD in middle-aged Korean men; however, serum testosterone levels and GH secretory capacity were not found to be correlated with BMD.
引用
收藏
页码:392 / 398
页数:7
相关论文
共 45 条
[1]
Association of hypogonadism and estradiol levels with bone mineral density in elderly men from the framingham study [J].
Amin, S ;
Zhang, YQ ;
Sawin, DT ;
Evans, SR ;
Hannan, MT ;
Kiel, DP ;
Wilson, PWF ;
Felson, DT .
ANNALS OF INTERNAL MEDICINE, 2000, 133 (12) :951-963
[2]
Low levels of estradiol are associated with vertebral fractures in older men, but not women:: The Rancho Bernardo study [J].
Barrett-Connor, E ;
Mueller, JE ;
Von Mühlen, DG ;
Laughlin, GA ;
Schneider, DL ;
Sartoris, DJ .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2000, 85 (01) :219-223
[3]
Factors associated with bone mineral density in middle-aged men [J].
Bendavid, EJ ;
Shan, J ;
BarrettConnor, E .
JOURNAL OF BONE AND MINERAL RESEARCH, 1996, 11 (08) :1185-1190
[4]
Boonen S, 1997, CALCIFIED TISSUE INT, V61, P173
[5]
Effect of testosterone and estradiol in a man with aromatase deficiency [J].
Carani, C ;
Qin, K ;
Simoni, M ;
FaustiniFustini, M ;
Serpente, S ;
Boyd, J ;
Korach, KS ;
Simpson, ER .
NEW ENGLAND JOURNAL OF MEDICINE, 1997, 337 (02) :91-95
[6]
Hormonal and anthropometric predictors of bone mass in healthy elderly men:: Major effect of sex hormone binding globulin, parathyroid hormone and body weight [J].
Díaz-Guerra, GM ;
Hawkins, F ;
Rapado, A ;
Díaz, MAR ;
Díaz-Curiel, M .
OSTEOPOROSIS INTERNATIONAL, 2001, 12 (03) :178-184
[7]
Relative contribution of lean and fat mass component to bone mineral density in males [J].
Douchi, T ;
Kuwahata, R ;
Matsuo, T ;
Uto, H ;
Oki, T ;
Nagata, Y .
JOURNAL OF BONE AND MINERAL METABOLISM, 2003, 21 (01) :17-21
[8]
LACK OF ASSOCIATION BETWEEN FREE TESTOSTERONE AND BONE-DENSITY SEPARATE FROM AGE IN ELDERLY MALES [J].
DRINKA, PJ ;
OLSON, J ;
BAUWENS, S ;
VOEKS, SK ;
CARLSON, I ;
WILSON, M .
CALCIFIED TISSUE INTERNATIONAL, 1993, 52 (01) :67-69
[9]
OSTEOPOROSIS IN MEN WITH IDIOPATHIC HYPOGONADOTROPIC HYPOGONADISM [J].
FINKELSTEIN, JS ;
KLIBANSKI, A ;
NEER, RM ;
GREENSPAN, SL ;
ROSENTHAL, DI ;
CROWLEY, WF .
ANNALS OF INTERNAL MEDICINE, 1987, 106 (03) :354-361
[10]
Bone mineral density in femoral neck is positively correlated to circulating insulin-like growth factor (IGF)-I and IGF-binding protein (IGFBP)-3 in Swedish men [J].
Gillberg, P ;
Olofsson, H ;
Mallmin, H ;
Blum, WF ;
Ljunghall, S ;
Nilsson, AG .
CALCIFIED TISSUE INTERNATIONAL, 2002, 70 (01) :22-29