Serum antibody decay in adults following natural respiratory syncytial virus infection

被引：95

作者：

Falsey, Ann R. ^{[1
]}

Singh, Harjot K. ^{[1
]}

Walsh, Edward E. ^{[1
]}

机构：

[1] Univ Rochester, Infect Dis Unit, Dept Med, Rochester Gen Hosp,Sch Med & Dent, Rochester, NY 14621 USA

来源：

JOURNAL OF MEDICAL VIROLOGY | 2006年 / 78卷 / 11期

关键词：

RSV; immunity; antibody; FUSION PROTEIN VACCINE; SUBUNIT VACCINE; IMMUNITY; RISK; AGE; IMMUNOGENICITY; INFLUENZA; CHILDREN; INFANTS;

D O I：

10.1002/jmv.20724

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Serum antibody decay following RSV infection in adults was examined to evaluate the durability of the immune response. Twenty subjects with RSV infection and 10 subjects who remained RSV uninfected had blood samples obtained over 16-25 months analyzed by microneutralization assay and enzyme immunoassay. The mean titers of infected subjects rose approximately eightfold post-infection. The mean rate of antibody decline was -0.20 log 2 titer per month which led to a >= fourfold drop in titer in 75% of subjects at 1 year. In contrast, titers of uninfected subjects were relatively stable. The partial immunity resulting from a boost in serum antibody following natural RSV infection in adults appears to be short lived.

引用

页码：1493 / 1497

页数：5

共 17 条

[1] Aging, immunity, and the varicella-zoster virus [J].