Apoptosis and cancer: the genesis of a research field

被引：618

作者：

Cotter, Thomas G. ^{[1
]}

机构：

[1] Natl Univ Ireland Univ Coll Cork, Dept Biochem, Tumour Biol Lab, Cork, Ireland

来源：

NATURE REVIEWS CANCER | 2009年 / 9卷 / 07期

关键词：

TUMOR-NECROSIS-FACTOR; APO-1/FAS RECEPTOR/LIGAND SYSTEM; DRUG-INDUCED APOPTOSIS; BCL-2 FAMILY PROTEINS; B-CELL LYMPHOMA; WILD-TYPE P53; C-MYC; PROGNOSTIC-SIGNIFICANCE; BREAST-CANCER; MONOCLONAL-ANTIBODY;

D O I：

10.1038/nrc2663

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In multicellular organisms, the total number of cells is a balance between the cell-generating effects of mitosis and cell death that is induced through apoptosis. A disruption of this delicate balance can lead to the development of cancer. This Timeline article focuses on how the field of apoptosis biology has developed in the context of its contribution to our understanding of cell death, or lack of it, in the development of malignant disease. It traces the course of research from key discoveries in fundamental biology to potential therapeutic applications.

引用

页码：501 / 507

页数：7

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