An Indole-Containing Dauer Pheromone Component with Unusual Dauer Inhibitory Activity at Higher Concentrations

被引：64

作者：

Butcher, Rebecca A. ^{[1
]}

Ragains, Justin R. ^{[1
]}

Clardy, Jon ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 14期

关键词：

NEMATODE CAENORHABDITIS-ELEGANS; C-ELEGANS; LARVAL DEVELOPMENT; CHEMOSENSORY NEURONS; INSULIN; GENE; ENCODES; MEMBER; DAF-2; LONGEVITY;

D O I：

10.1021/ol901011c

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学];

摘要：

In Caenorhabditis elegans, the dauer pheromone, which consists of a number of derivatives of the 3,6-dideoxysugar ascarylose, is the primary cue for entry into the stress-resistant, "nonaging" dauer larval stage. Here, using activity-guided fractionation and NMR-based structure elucidation, a structurally novel, indole-3-carboxyl-modified ascaroside is identified that promotes dauer formation at low nanomolar concentrations but inhibits dauer formation at higher concentrations.

引用

页码：3100 / 3103

页数：4

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