Comparative genomics of the eukaryotes

被引：1289

作者：

Rubin, GM ^{[1
]}

Yandell, MD

Wortman, JR

Miklos, GLG

Nelson, CR

Hariharan, IK

Fortini, ME

Li, PW

Apweiler, R

Fleischmann, W

Cherry, JM

Henikoff, S

Skupski, MP

Misra, S

Ashburner, M

Birney, E

Boguski, MS

Brody, T

Brokstein, P

Celniker, SE

Chervitz, SA

Coates, D

Cravchik, A

Gabrielian, A

Galle, RF

Gelbart, WM

George, RA

Goldstein, LSB

Gong, FC

Guan, P

Harris, NL

Hay, BA

Hoskins, RA

Li, JY

Li, ZY

Hynes, RO

Jones, SJM

Kuehl, PM

Lemaitre, B

Littleton, JT

Morrison, DK

Mungall, C

O'Farrell, PH

Pickeral, OK

Shue, C

Vosshall, LB

Zhang, J

Zhao, Q

Zheng, XQH

Zhong, F

机构：

[1] Univ Calif Berkeley, Howard Hughes Med Inst, Berkeley, CA 94720 USA

[2] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley Drosophila Genome Project, Berkeley, CA 94720 USA

[3] Celera Genom, Rockville, MD 20850 USA

[4] Genetixxpress, Sydney, NSW 2108, Australia

[5] Massachusetts Gen Hosp, Ctr Canc, Charlestown, MA 02129 USA

[6] Univ Penn, Sch Med, Dept Genet, Philadelphia, PA 19104 USA

[7] EMBL, EBI, Cambridge CB10 1SD, England

[8] Stanford Univ, Dept Genet, Stanford, CA 94305 USA

[9] Fred Hutchinson Canc Res Ctr, Howard Hughes Med Inst, Seattle, WA 98109 USA

[10] Natl Lib Med, Natl Ctr Biotechnol Informat, NIH, Bethesda, MD 20894 USA

[11] NINDS, Neurogenet Unit, Neurochem Lab, NIH, Bethesda, MD 20892 USA

[12] Univ Calif Berkeley, Lawrence Berkeley Lab, Berkeley Drosophila Genome Project, Berkeley, CA 94720 USA

[13] Neomorphic, Berkeley, CA 94710 USA

[14] Univ Leeds, Sch Biol, Leeds LS2 9JT, W Yorkshire, England

[15] Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA

[16] Univ Calif San Diego, Howard Hughes Med Inst, Dept Cellular & Mol Med, La Jolla, CA 92093 USA

[17] Univ Calif San Diego, Howard Hughes Med Inst, Dept Pharmacol, La Jolla, CA 92093 USA

[18] CALTECH, Div Biol, Pasadena, CA 91125 USA

[19] MIT, Howard Hughes Med Inst, Cambridge, MA 02139 USA

[20] BC Canc Res Ctr, Genome Sequence Ctr, Vancouver, BC V52 4E6, Canada

[21] Univ Maryland, Cell & Mol Biol Program, Baltimore, MD 21201 USA

[22] CNRS, Ctr Genet Mol, F-91198 Gif Sur Yvette, France

[23] MIT, Ctr Learning & Memory, Cambridge, MA 02139 USA

[24] NCI, Regulat Cell Growth Lab, Div Basic Sci, Frederick Canc Res & Dev Ctr,NIH, Ft Detrick, MD 21702 USA

[25] Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94143 USA

[26] Columbia Univ, Ctr Neurobiol & Behav, New York, NY 10032 USA

[27] Baylor Coll Med, Human Genome Sequencing Ctr, Dept Mol & Human Genet, Houston, TX 77030 USA

来源：

SCIENCE | 2000年 / 287卷 / 5461期

关键词：

D O I：

10.1126/science.287.5461.2204

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A comparative analysis of the genomes of Drosophila melanogaster, Caenorhabditis elegans, and Saccharomyces cerevisiae-and the proteins they are predicted to encode-was undertaken in the context of cellular, developmental, and evolutionary processes. The nonredundant protein sets of flies and worms are similar in size and are only twice that of yeast, but different gene families are expanded in each genome, and the multidomain proteins and signaling pathways of the fly and worm are far more complex than those of yeast. The fly has orthologs to 177 of the 289 human disease genes examined and provides the foundation for rapid analysis of some of the basic processes involved in human disease.

引用

页码：2204 / 2215

页数：12

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