Expression pattern of protease activated receptors in lymphoid cells

被引：24

作者：

Lopez, Mercedes L. ^{[1
,3
]}

Soriano-Sarabia, Natalia ^{[2
]}

Bruges, Gustavo ^{[1
]}

Marquez, Maria Elena ^{[1
]}

Preissner, Klaus T. ^{[3
]}

Schmitz, M. Lienhard ^{[3
]}

Hackstein, Holger ^{[2
]}

机构：

[1] Inst Venezolano Invest Cient, Caracas 1020A, Venezuela

[2] Univ Giessen, Inst Clin Immunol & Transfus Med, D-35390 Giessen, Germany

[3] Univ Giessen, Fac Med, Inst Biochem, D-35392 Giessen, Germany

来源：

CELLULAR IMMUNOLOGY | 2014年 / 288卷 / 1-2期

关键词：

Protease-activated receptors; Lymphocytes; FACS; Natural killer cells; gamma delta cells; CD4+T cells; CD8+T cells; B cells; THROMBIN RECEPTOR; HUMAN EOSINOPHILS; T-CELLS; RESPONSES; RELEASE; CLONING; PAR1;

D O I：

10.1016/j.cellimm.2014.02.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Protease-activated receptors (PARs) are a subfamily of four G-protein-coupled receptors mediating multiple functions. PARs expression was studied in subpopulations of human lymphocytes. Our results indicate that natural killer cells expressed mRNA for PAR(1), PAR(2) and PAR(3), CD4+ T cells expressed PARI and PAR(2), while gamma delta and CD8+ T cells only expressed PAR(1) PAR(4) was absent at mRNA level and B cells did not express any PAR. Analyses of the cell surface PARs expression by flow cytometry were consistent with the mRNA data and also between different donors. PAR(1) is the most abundant member of the PAR family present in lymphocytes. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：47 / 52

页数：6

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