Cell-cell communication in the pituitary: orchestrator of pulsatile growth hormone secretion?

被引：4

作者：

Asa, Sylvia L. ^{[1
]}

Tannenbaum, Gloria S.

机构：

[1] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON M5G 2C4, Canada

[2] Univ Hlth Network, Dept Pathol, Toronto, ON M5G 2C4, Canada

[3] Toronto Med Labs, Toronto, ON M5G 2C4, Canada

[4] McGill Univ, Dept Pediat, Montreal, PQ H3H 1P3, Canada

[5] McGill Univ, Dept Neurol & Neurosurg, Montreal, PQ H3H 1P3, Canada

[6] Montreal Childrens Hosp, Res Inst, Neuropeptide Physiol Lab, Montreal, PQ H3H 1P3, Canada

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2006年 / 17卷 / 08期

关键词：

D O I：

10.1016/j.tem.2006.08.004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hormone secretion is dependent on intracellular and extracellular regulation of hormone synthesis and release, including classical endocrine and paracrine mechanisms and transcription factors that determine cell differentiation and hormone gene transcription. Recent research has identified direct cell-cell communication in a three-dimensional network of pituitary growth hormone-secreting cells connected by adherens junctions. This challenges the conventional view of endocrine cells as collections of dispersed cells and suggests that physical connectivity mediates cellular responses to coordinate pulsatile secretion.

引用

页码：299 / 300

页数：2

共 11 条

[1] Biological networks: The tinkerer as an engineer [J].

Alon, U .

SCIENCE, 2003, 301 (5641) :1866-1867

[2]

Asa SL, 2004, FRONT HORM RES, V32, P1

[3] EVIDENCE FOR FUNCTIONAL COMMUNICATION BETWEEN FOLLICULO-STELLATE CELLS AND HORMONE-SECRETING CELLS IN PERIFUSED ANTERIOR-PITUITARY CELL AGGREGATES [J].

BAES, M ;

ALLAERTS, W ;

DENEF, C .

ENDOCRINOLOGY, 1987, 120 (02) :685-691

[4] Revealing the large-scale network organization of growth hormone-secreting cells [J].

Bonnefont, X ;

Lacampagne, A ;

Sanchez-Hormigo, A ;

Fino, E ;

Creff, A ;

Mathieu, MN ;

Smallwood, S ;

Carmignac, D ;

Fontanaud, P ;

Travo, P ;

Alonso, G ;

Courtois-Coutry, N ;

Pincus, SM ;

Robinson, ICAF ;

Mollard, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (46) :16880-16885

[5] Folliculostellate cell network:: A route for long-distance communication in the anterior pituitary [J].

Fauquier, T ;

Guérineau, NC ;

McKinney, RA ;

Bauer, K ;

Mollard, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (15) :8891-8896

[6]

HORVATH E, 1977, IRCS (International Research Communications System) Medical Science Library Compendium, V5, P511

[7]

HORVATH E, 1974, AM J PATHOL, V77, P199

[8] SEXUAL DIMORPHISM IN THE CONTROL OF GROWTH-HORMONE SECRETION [J].

JANSSON, JO ;

EDEN, S ;

ISAKSSON, O .

ENDOCRINE REVIEWS, 1985, 6 (02) :128-150

[9] Ghrelin is a growth-hormone-releasing acylated peptide from stomach [J].

Kojima, M ;

Hosoda, H ;

Date, Y ;

Nakazato, M ;

Matsuo, H ;

Kangawa, K .

NATURE, 1999, 402 (6762) :656-660

[10]

Robinson ICAF., 1999, HAND PHYSL, V5, P329

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