Receptor-mediated immunoglobulin G transport across mucosal barriers in adult life: Functional expression of FcRn in the mammalian lung

被引:295
作者
Spiekermann, GM
Finn, PW
Ward, ES
Dumont, J
Dickinson, BL
Blumberg, RS
Lencer, WI
机构
[1] Harvard Digest Dis Ctr, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Childrens Hosp, Combine Program Pediat Gastroenterol & Nutr, Boston, MA 02115 USA
[3] Harvard Univ, Sch Med, Div Pulm, Boston, MA 02115 USA
[4] Harvard Univ, Sch Med, Div Gastroenterol, Brigham & Womens Hosp, Boston, MA 02115 USA
[5] Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA
[6] Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA
[7] Univ Texas, SW Med Ctr, Ctr Immunol, Dallas, TX 75390 USA
[8] Univ Texas, SW Med Ctr, Ctr Canc Immunobiol, Dallas, TX 75390 USA
[9] Syntonix Pharmaceut, Waltham, MA 02451 USA
关键词
FcRn; transcytosis; IgG; epithelial cells; lung;
D O I
10.1084/jem.20020400
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Mucosal secretions of the human gastrointestinal, respiratory, and genital tracts contain the immunoglobulins (Ig)G and secretory IgA (sIgA) that function together in host defense. Exactly how IgG crosses epithelia barriers to function in mucosal immunity remains unknown. Here, we test the idea that the MHC class I-related Fc-receptor, FcRn, transports IgG across the mucosal surface of the human and mouse lung from lumen to serosa. We find that bronchial epithelia cells of the human, nonhuman primate, and mouse, express FcRn in adult-life, and demonstrate FcRn-dependent absorption of a bioactive Fc-fusion protein across the respiratory epithelium of the mouse in vivo. Thus, IgG, like dimeric IgA, can cross epithelial barriers by receptor-mediated transcytosis in adult animals. These data show that mucosal surfaces that express FcRn reabsorb IgG and explain a mechanism by which IgG may act in immune surveillance to retrieve lumenal antigens for processing in the lamina propria or systemically.
引用
收藏
页码:303 / 310
页数:8
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