Understanding the stepwise synthesis of glycolipids

被引：42

作者：

Maccioni, HJF ^{[1
]}

Giraudo, CG ^{[1
]}

Daniotti, JL ^{[1
]}

机构：

[1] Univ Nacl Cordoba, Fac Ciencias Quim, Dept Quim Biol, CONICET,CIQUIBIC, RA-5000 Cordoba, Argentina

来源：

NEUROCHEMICAL RESEARCH | 2002年 / 27卷 / 7-8期

关键词：

glycolipid synthesis; glycosyltransferases; Golgi complex organization;

D O I：

10.1023/A:1020271932760

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Glycolipid expression is highly regulated during development and differeniation. The control relies mainly on transcriptional modulation of key glycosyltransferases acting at the branching points of the pathway of biosynthesis. Transferases are Golgi residents that depend on N-glycosylation and oligosaccharide processing for proper folding in the endoplasmic reticulum. The N-terminal domain bears information for their transport to the Golgi, retention in the organelle and differential concentration in sub-Golgi compartments. In the Golgi, some transferases associate forming functional multienzyme complexes. It is envisaged that the machinery for synthesis in the Golgi complex, and its dynamics, constitute a potential target for fine tuning of the control of glycolipid expression according to cell demands.

引用

页码：629 / 636

页数：8

共 59 条

[1] The Sar1 GTPase coordinates biosynthetic cargo selection with endoplasmic reticulum export site assembly [J].