The immune response attenuates growth and nutrient storage in Drosophila by reducing insulin signaling

被引:221
作者
DiAngelo, Justin R. [3 ]
Bland, Michelle L. [3 ]
Bambina, Shelly [1 ,2 ]
Cherry, Sara [1 ,2 ]
Birnbaum, Morris J. [3 ]
机构
[1] Univ Penn, Dept Microbiol, Sch Med, Philadelphia, PA 19104 USA
[2] Univ Penn, Penn Genome Frontiers Inst, Sch Med, Philadelphia, PA 19104 USA
[3] Univ Penn, Sch Med, Inst Diabet Obes & Metab, Philadelphia, PA 19104 USA
基金
美国国家卫生研究院;
关键词
fat body; immunity; Toll; insulin; RECEPTOR SUBSTRATE-1; DEFICIENCY IMD; LIFE-SPAN; CELL; INFLAMMATION; INFECTION; PATHWAYS; METABOLISM; RESISTANCE; PROTEIN;
D O I
10.1073/pnas.0906749106
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Innate immunity is the primary and most ancient defense against infection. Although critical to survival, coordinating protection against a foreign organism is energetically costly, creating the need to reallocate substrates from nonessential functions, such as growth and nutrient storage. However, the mechanism by which infection or inflammation leads to a reduction in energy utilization by these dispensable processes is not well understood. Here, we demonstrate that activation of the Toll signaling pathway selectively in the fat body, the major immune and lipid storage organ of the fruit fly, Drosophila melanogaster, leads to both induction of immunity and reallocation of resources. Toll signaling in the fat body suppresses insulin signaling both within these cells and non-autonomously throughout the organism, leading to a decrease in both nutrient stores and growth. These data suggest that communication between these two regulatory systems evolved as a means to divert energy in times of need from organismal growth to the acute requirement of combating infection.
引用
收藏
页码:20853 / 20858
页数:6
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