Hepatocyte growth factor: from diagnosis to clinical applications

被引：162

作者：

Funakoshi, H ^{[1
]}

Nakamura, T ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Med, Course Adv Med, Div Mol Regenerat Med, Suita, Osaka 5650871, Japan

来源：

CLINICA CHIMICA ACTA | 2003年 / 327卷 / 1-2期

关键词：

HGF; c-Met; serum level; tissue level; disease; gene therapy;

D O I：

10.1016/S0009-8981(02)00302-9

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Hepatocyte growth factor (HGF), initially identified and molecularly cloned as a potent mitogen of primary cultured hepatocytes, has multiple activities in a variety of tissues during the course of development and also in various disease states. HGF plays key roles in the attenuation of disease progression as an intrinsic repair factor. It is also evident that HGF levels are regulated under different conditions, for example, during the course of pregnancy, aging, and disease. This review focuses on the levels of HGF in normal and pathophysiological situations and examines the relationships between HGF levels and disease, disease stage, and disease prognosis. The clinical potential of HGF as a treatment for subjects with various diseases is also given attention. (C) 2002 Elsevier Science B.V All rights reserved.

引用

页码：1 / 23

页数：23

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