Regulation of pathogenesis and immunity in helminth infections

被引：171

作者：

Maizels, Rick M. ^{[1
,2
]}

Pearce, Edward J. ^{[3
]}

Artis, David ^{[4
]}

Yazdanbakhsh, Maria ^{[5
]}

Wynn, Thomas A. ^{[6
]}

机构：

[1] Univ Edinburgh, Ctr Immun Infect & Evolut, Edinburgh, Midlothian, Scotland

[2] Univ Edinburgh, Inst Immunol & Infect Res, Edinburgh, Midlothian, Scotland

[3] Trudeau Inst, Saranac Lake, NY 12983 USA

[4] Univ Penn, Dept Pathobiol, Sch Vet Med, Philadelphia, PA 19104 USA

[5] Leiden Univ, Dept Parasitol, Med Ctr, Leiden, Netherlands

[6] NIAID, Immunopathogenesis Sect, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2009年 / 206卷 / 10期

基金：

英国惠康基金;

关键词：

EGG-INDUCED IMMUNOPATHOLOGY; FOLLICULAR HELPER-CELLS; CD4(+) T-CELLS; SCHISTOSOMA-MANSONI; MOLECULAR-MECHANISMS; FILARIAL INFECTION; TH2; RESPONSES; MOUSE MODELS; EXPRESSION; INFLAMMATION;

D O I：

10.1084/jem.20091903

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Helminths are multicellular eukaryotic parasites that infect over one quarter of the world's population. Through coevolution with the human immune system, these organisms have learned to exploit immunoregulatory pathways, resulting in asymptomatic tolerance of infections in many individuals. When infections and the resulting immune responses become dysregulated, however, acute and chronic pathologies often develop. A recent international meeting focused on how these parasites modulate host immunity and how control of parasitic and immunopathological disease might be achieved.

引用

页码：2059 / 2066

页数：8

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