Lipoxygenases - Structure and reaction mechanism

被引：301

作者：

Andreou, Alexandra ^{[1
]}

Feussner, Ivo ^{[1
]}

机构：

[1] Univ Gottingen, Albrecht von Haller Inst Plant Sci, Dept Plant Biochem, D-37077 Gottingen, Germany

来源：

PHYTOCHEMISTRY | 2009年 / 70卷 / 13-14期

关键词：

Dioxygenases; Fatty acid peroxidation; Lipid peroxidation; Octadecanoids; Stereo- and regio-specific dioxygenation; Substrate specificity; LIPID BODY LIPOXYGENASE; DUAL POSITIONAL SPECIFICITY; STORAGE LIPIDS; ACTIVE-SITE; FATTY-ACIDS; SOYBEAN LIPOXYGENASE-1; CHOLESTEROL ESTERS; LINOLEIC-ACID; SP PCC-7120; OXYGENATION;

D O I：

10.1016/j.phytochem.2009.05.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lipid oxidation is a common metabolic reaction in all biological systems, appearing in developmentally regulated processes and as response to abiotic and biotic stresses. Products derived from lipid oxidation processes are collectively named oxylipins. Initial lipid oxidation may either occur by chemical reactions or is derived from the action of enzymes. In plants this reaction is mainly catalyzed by lipoxygenase (LOXs) enzymes and during recent years analysis of different plant LOXs revealed insights into their enzyme mechanism. This review aims at giving an overview of concepts explaining the catalytic mechanism of LOXs as well as the different regio- and stereo-specificities of these enzymes. (c) 2009 Elsevier Ltd. All rights reserved.

引用

页码：1504 / 1510

页数：7

共 61 条

[1] Properties of a mini 9R-lipoxygenase from Nostoc sp PCC 7120 and its mutant forms [J].

Andreou, Alexandra-Zoi ;

Vanko, Marian ;

Bezakova, Lydia ;

Feussner, Ivo .

PHYTOCHEMISTRY, 2008, 69 (09) :1832-1837

[2] On the Substrate Binding of Linoleate 9-Lipoxygenases [J].

Andreou, Alexandra-Zoi ;

Hornung, Ellen ;

Kunze, Susan ;

Rosahl, Sabine ;

Feussner, Ivo .

LIPIDS, 2009, 44 (03) :207-215

[3]

ANDREOU AZ, 2009, PROG LIPID RES, DOI DOI 10.1016/J.PLIPRES.2009.1002.1002

[4] Change in the positional specificity of lipoxygenase 1 due to insertion of fatty acids into phosphatidylcholine deoxycholate mixed micelles [J].

Began, G ;

Sudharshan, E ;

Rao, AGA .

BIOCHEMISTRY, 1999, 38 (42) :13920-13927

[5] THE OXYGENATION OF CHOLESTEROL ESTERS BY THE RETICULOCYTE LIPOXYGENASE [J].

BELKNER, J ;

WIESNER, R ;

KUHN, H ;

LANKIN, VZ .

FEBS LETTERS, 1991, 279 (01) :110-114

[6] The rabbit 15-lipoxygenase preferentially oxygenates LDL cholesterol esters, and this reaction does not require vitamin E [J].

Belkner, J ;

Stender, H ;

Kühn, H .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (36) :23225-23232

[7] Impact of phyto-oxylipins in plant defense [J].

Blée, E .

TRENDS IN PLANT SCIENCE, 2002, 7 (07) :315-321

[8] Lipoxygenases: Occurrence, functions, catalysis, and acquisition of substrate [J].

Brash, AR .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (34) :23679-23682

[9] Burying a charge [J].

Browner, MF ;

Gillmor, SA ;

Fletterick, R .

NATURE STRUCTURAL BIOLOGY, 1998, 5 (03) :179-179

[10] A comprehensive model of positional and stereo control in lipoxygenases [J].

Coffa, G ;

Schneider, C ;

Brash, AR .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 338 (01) :87-92

← 1 2 3 4 5 6 7 →