PGC-1α in aging and anti-aging interventions

被引：128

作者：

Anderson, Rozalyn ^{[1
,2
]}

Prolla, Tomas ^{[3
]}

机构：

[1] Wisconsin Natl Primate Res Ctr, Madison, WI 53715 USA

[2] VA Hosp, GRECC, Madison, WI 53715 USA

[3] Univ Wisconsin, Dept Genet, Madison, WI 53706 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS | 2009年 / 1790卷 / 10期

关键词：

Aging; Anti-aging; Caloric restriction; PGC-1; alpha; Mitochondrial dysfunction; Aging associated disease; Resveratrol; ACTIVATED-RECEPTOR-GAMMA; TRANSCRIPTIONAL COACTIVATOR PGC-1-ALPHA; GENE-EXPRESSION PROFILE; HUMAN SKELETAL-MUSCLE; MITOCHONDRIAL OXYGEN-CONSUMPTION; PROTEIN-KINASE ACTIVATION; ADIPOSE-TISSUE; CALORIC RESTRICTION; INSULIN-RESISTANCE; ENERGY-METABOLISM;

D O I：

10.1016/j.bbagen.2009.04.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Deregulation of mitochondrial function is a common feature in multiple aspects of aging. In addition to playing a role in aging-associated disease, decline in mitochondrial energy metabolism is likely to be important in the development of metabolic disease. Furthermore, altered mitochondrial function is a conserved feature in caloric restriction - a dietary intervention that delays aging in diverse species. The transcriptional co-activator PGC-1 alpha is a critical regulator of mitochondrial energy metabolism and biogenesis. PGC-1 alpha is uniquely poised as a potential target for correcting the effects of age on mitochondrial decline. We describe the cellular and tissue specific mechanisms of PGC-1 alpha regulation and illustrate how these pathways may be involved in the aging process. Published by Elsevier B.V.

引用

页码：1059 / 1066

页数：8

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