Inhibitory effect of chemical constituents from Artemisia scoparia Waldst. et Kit. on triglyceride accumulation in 3T3-L1 cells and nitric oxide production in RAW 264.7 cells

被引：33

作者：

Yahagi, Tadahiro ^{[1
]}

Yakura, Naoyuki ^{[1
]}

Matsuzaki, Keiichi ^{[1
]}

Kitanaka, Susumu ^{[1
]}

机构：

[1] Nihon Univ, Sch Pharm, Funabashi, Chiba 2748555, Japan

来源：

JOURNAL OF NATURAL MEDICINES | 2014年 / 68卷 / 02期

关键词：

Artemisia scoparia Waldst. et Kit; Chromane; Triglyceride; Nitric oxide; DIFFERENTIATION; FLAVONOIDS; EXTRACT; OBESITY; LEAVES; ACID; FLAVANONES; SYNTHASE; ANALOGS;

D O I：

10.1007/s11418-013-0799-3

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

We investigated the anti-obesity effect of the aerial part of Artemisia scoparia Waldst. et Kit. (Compositae). An 80 % aqueous EtOH extract of the aerial part inhibited triglyceride (TG) accumulation and the nitric oxide (NO) production activity. A new chromane derivative was isolated from the aerial part of A. scoparia Waldst. et Kit. along with 18 known compounds. The structure of the new chromane, scopariachromane (1), was elucidated by spectroscopic analyses. The inhibitory effects of the compounds on TG accumulation activity were examined. Among these, cirsiliol (11) inhibited TG accumulation in 3T3-L1 preadipocytes. Jaceosidin (12) inhibited NO production in a murine macrophage-like cell line (RAW 264.7). These results indicate that the 80 % aqueous EtOH extract and compounds isolated from the aerial part of A. scoparia Waldst. et Kit. may improve obesity-related insulin resistance.

引用

页码：414 / 420

页数：7

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