Antiinflammatory activity of coumarins from Santolina oblongifolia

被引：115

作者：

Silvan, AM ^{[1
]}

Abad, MJ ^{[1
]}

Bermejo, P ^{[1
]}

Sollhuber, M ^{[1
]}

Villar, A ^{[1
]}

机构：

[1] UNIV COMPLUTENSE MADRID, FAC PHARM, DEPT ORGAN CHEM, E-28040 MADRID, SPAIN

来源：

JOURNAL OF NATURAL PRODUCTS | 1996年 / 59卷 / 12期

基金：

俄罗斯基础研究基金会;

关键词：

D O I：

10.1021/np960422f

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Four coumarins were isolated from the EtOAc extract of the flower-tops of Santolina oblongifolia Boiss. (Compositae). They were identified as 7-methoxycoumarin (herniarin) (1), 6,7-dihydroxycoumarin (aesculetin) (2), 6-methoxy-7-glucosidylcoumarin (scopolin) (3), and 6-hydroxy-7-methoxycoumarin (scopoletin) (4). This is the first report of the isolation of aesculetin and scopolin from the genus Santolina. The isolated coumarins showed marked activity as inhibitors of eicosanoid-release from ionophore-stimulated mouse peritoneal macrophages.

引用

页码：1183 / 1185

页数：3

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