Why animal studies are often poor predictors of human reactions to exposure

被引：254

作者：

Bracken, Michael B. ^{[1
,2
]}

机构：

[1] Yale Univ, Sch Med, Ctr Perinatal Pediat & Environm Epidemiol, New Haven, CT 06510 USA

[2] Yale Univ, Sch Publ Hlth, Ctr Perinatal Pediat & Environm Epidemiol, New Haven, CT 06510 USA

来源：

JOURNAL OF THE ROYAL SOCIETY OF MEDICINE | 2009年 / 102卷 / 03期

关键词：

SYSTEMATIC REVIEWS; DRUGS; MODELS; EXPERIMENTATION; CHEMOPREVENTION; METAANALYSIS; METABOLISM; EFFICACY; TGN1412; IMPROVE;

D O I：

10.1258/jrsm.2008.08k033

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

[No abstract available]

引用

页码：120 / 122

页数：3

共 26 条

[1]

*AM COUNC SCI HLTH, 2006, AM WAR CARC REASS US

[2]

Bebarta V, 2003, ACAD EMERG MED, V10, P684, DOI 10.1111/j.1553-2712.2003.tb00056.x

[3]

BRODIE BB, 1962, CLIN PHARMACOL THER, V3, P374

[4]

Corpet DE, 2003, CANCER EPIDEM BIOMAR, V12, P391

[5] How good are rodent models of carcinogenesis in predicting efficacy in humans? A systematic review and meta-analysis of colon chemoprevention in rats, mice and men [J].

Corpet, DE ;

Pierre, F .

EUROPEAN JOURNAL OF CANCER, 2005, 41 (13) :1911-1922

[6]

FLOREY H. W., 1951, JOUR HIST MED AND ALLIED SCI, V6, P302

[7] THE PROPER STUDY OF MANKIND IS MAN [J].

GOLD, H .

AMERICAN JOURNAL OF MEDICINE, 1952, 12 (06) :619-620

[8] Translation of research evidence from animals to humans [J].

Hackam, Daniel G. ;

Redelmeier, Donald A. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2006, 296 (14) :1731-+

[9] Nimodipine in animal model experiments of focal cerebral ischemia - A systematic review [J].

Horn, J ;

de Haan, RJ ;

Vermeulen, M ;

Luiten, PGM ;

Limburg, M .

STROKE, 2001, 32 (10) :2433-2438

[10] Establishing risk of human experimentation with drugs: lessons from TGN1412 [J].

Kenter, M. J. H. ;

Cohen, A. F. .

LANCET, 2006, 368 (9544) :1387-1391

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