Regulation of p53 family members by the ubiquitin-like SUMO system

被引：80

作者：

Stehmeier, Per ^{[1
]}

Muller, Stefan ^{[1
]}

机构：

[1] Max Planck Inst Biochem, Dept Mol Cell Biol, D-82152 Martinsried, Germany

来源：

DNA REPAIR | 2009年 / 8卷 / 04期

关键词：

SUMO; p53; family; p63; p73; Ubiquitin; PREMATURE SENESCENCE; NUCLEAR-BODIES; POSTTRANSLATIONAL MODIFICATIONS; TRANSCRIPTIONAL REGULATION; PROTEIN INHIBITOR; PIAS PROTEINS; ONCOGENIC RAS; E3; LIGASE; IN-VITRO; C-JUN;

D O I：

10.1016/j.dnarep.2009.01.002

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

p53 and its cousins p63 and p73 are critical regulators of the genotoxic stress response in mammalian cells. Their activity is controlled by an intricate network of post-translational modifications. The ubiquitin-like SUMO system targets all three family members and modulates their transcriptional activity, stability or subcellular trafficking. While the SUMO system appears to primarily exert a negative regulatory function on p73 and p63, both activating and repressing activities have been reported on p53. Here we will give a synopsis of the multifaceted effects of SUMO on p53 family members. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：491 / 498

页数：8

共 73 条

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