No association of the-48CT polymorphism of the presenilin 1 gene with Alzheimer disease in a late-onset sporadic population

被引：6

作者：

Araria-Goumidi, L

Huguet, JB

Lambert, JC

Frigard, B

Cottel, D

Amouyel, P

Chartier-Harlin, MC

机构：

[1] Inst Pasteur, INSERM, U508, F-59019 Lille, France

[2] CHI Wasquehal Moulinel, Wasquehal, France

来源：

JOURNAL OF NEURAL TRANSMISSION | 2002年 / 109卷 / 7-8期

关键词：

Alzheimer's disease; presenilin; 1; polymorphism; association;

D O I：

10.1007/s007020200085

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Recently, a polymorphism located in the promoter of the presenilin 1 gene was associated with early-onset Alzheimer disease (EOAD). To determine if this polymorphism is also a risk factor for late-onset Alzheimer's disease (LOAD), we analysed its potential impact in a French population of LOAD patients only. Genotype and allelic distributions of the -48CT polymorphism were similar for controls and AD patients. Our result suggests that this polymorphism may not influence the development of LOAD. Other studies need to be undertaken to confirm this association restricting the impact of this polymorphism to EOAD patients.

引用

页码：1023 / 1027

页数：5

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