Highly efficient synthesis of β-amino acid derivatives via asymmetric hydrogenation of unprotected enamines

被引：201

作者：

Hsiao, Y ^{[1
]}

Rivera, NR

Rosner, T

Krska, SW

Njolito, E

Wang, F

Sun, YK

Armstrong, JD

Grabowski, EJJ

Tillyer, RD

Spindler, F

Malan, C

机构：

[1] Merck & Co Inc, Merck Res Labs, Dept Proc Res, Rahway, NJ 07065 USA

[2] Merck & Co Inc, Merck Res Labs, Dept Analyt Res, Rahway, NJ 07065 USA

[3] Solvias AG, Basel, Switzerland

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2004年 / 126卷 / 32期

关键词：

D O I：

10.1021/ja047901i

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A direct asymmetric hydrogenation of unprotected enamino esters and amides is described. Catalyzed by Rh complexes with Josiphos-type chiral ligands, this method gives β-amino esters and amides in high yield and high ee (93-97% ee). No acyl protection/deprotection is required. Copyright © 2004 American Chemical Society.

引用

页码：9918 / 9919

页数：2

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