Efficient removal of sugar O-tosyl groups and heterocycle halogens from purine nucleosides with sodium naphthalenide

被引：7

作者：

Lewandowska, E ^{[1
]}

Neschadimenko, V ^{[1
]}

Wnuk, SF ^{[1
]}

Robins, MJ ^{[1
]}

机构：

[1] BRIGHAM YOUNG UNIV,DEPT CHEM & BIOCHEM,PROVO,UT 84602

来源：

TETRAHEDRON | 1997年 / 53卷 / 18期

关键词：

D O I：

10.1016/S0040-4020(97)00313-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Sodium naphthalenide effects removal of 2'-, 3'-, or 5'-O-tosyl groups from the sugar, and 2-, 6-, or 8-halogens from purine nucleosides. An improved tosyl protection strategy was developed for the synthesis of 9-(3-deoxy-3-fluoro-beta-D-xylofuranosyl)adenine from 2',5'-di-O-tosyladenosine. (C) 1997 Elsevier Science Ltd.

引用

页码：6295 / 6302

页数：8

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