Degradation of chitosan and chemically modified chitosan by viscosity measurements

被引:18
作者
Agnihotri, Sunil A. [1 ]
Kulkarni, Vaibhav D. [1 ]
Kulkarni, Anandrao R. [1 ]
Aminabhavi, Tejraj M. [1 ]
机构
[1] Karnatak Univ, Drug Delivery Div, Ctr Excellence Polymer Sci, Dharwad 580003, Karnataka, India
关键词
chitosan; degradation; chemical modification; viscosity;
D O I
10.1002/app.24663
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
Chitosan and chitosan-grafted-acrylamide were subjected to degradation in the presence and absence of a degrading agent at 37 degrees C by measuring the viscosity of polymer solutions. Extracts from the fresh rat droppings were used as the degrading agent to simulate the environmental degrading conditions. Results of this study indicated that the concentrations of acetic acid in solution and chemical modifications of chitosan affected the degradation both in the presence as well as in the absence of a degrading agent. Reduction in viscosity was used to study the degradation. Chitosan was stable up to sixteen days of immersion in acetic acid without the degrading agent, but it readily underwent degradation in the presence of a degrading agent. Chitosan-grafted-acrylamide also followed the same trend, but the extent of reduction in viscosity was much less than pure chitosan, indicating that the chemical modification has improved the stability of the polymer. (c) 2006 Wiley Periodicals, Inc.
引用
收藏
页码:3255 / 3258
页数:4
相关论文
共 9 条
[1]   Recent advances on chitosan-based micro- and nanoparticles in drug delivery [J].
Agnihotri, SA ;
Mallikarjuna, NN ;
Aminabhavi, TM .
JOURNAL OF CONTROLLED RELEASE, 2004, 100 (01) :5-28
[2]   Synthesis and characterization of polyacrylamide-grafted chitosan hydrogel microspheres for the controlled release of indomethacin [J].
Kumbar, SG ;
Soppimath, KS ;
Aminabhavi, TM .
JOURNAL OF APPLIED POLYMER SCIENCE, 2003, 87 (09) :1525-1536
[3]   Some physicochemical measurements of chitosan polymer in acetic acid-water mixtures at different temperatures [J].
Kurkuri, MD ;
Kulkarni, AR ;
Aminabhavi, TM .
JOURNAL OF APPLIED POLYMER SCIENCE, 2002, 86 (02) :526-529
[4]   Degradation of partially N-acetylated chitosans with hen egg white and human lysozyme [J].
Nordtveit, RJ ;
Varum, KM ;
Smidsrod, O .
CARBOHYDRATE POLYMERS, 1996, 29 (02) :163-167
[5]  
Riccardo A.A., 1977, CHITIN
[6]   The degradation of chitosan with the aid of lipase from Rhizopus japonicus for the production of soluble chitosan [J].
Shin, SS ;
Lee, YC ;
Lee, C .
JOURNAL OF FOOD BIOCHEMISTRY, 2001, 25 (04) :307-321
[7]   Molecular parameters of chitosans depolymerized with the aid of papain [J].
Terbojevich, M ;
Cosani, A ;
Muzzarelli, RAA .
CARBOHYDRATE POLYMERS, 1996, 29 (01) :63-68
[8]   In vitro degradation rates of partially N-acetylated chitosans in human serum [J].
Varum, KM ;
Myhr, MM ;
Hjerde, RJN ;
Smidsrod, O .
CARBOHYDRATE RESEARCH, 1997, 299 (1-2) :99-101
[9]   In vitro degradation of chitosan by bacterial enzymes from rat cecal and colonic contents [J].
Zhang, H ;
Neau, SH .
BIOMATERIALS, 2002, 23 (13) :2761-2766