Genomic amplicons target vesicle recycling in breast cancer

被引：35

作者：

Mills, Gordon B. ^{[1
]}

Jurisica, Igor ^{[2
]}

Yarden, Yosef ^{[3
]}

Norman, Jim C. ^{[4
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Syst Biol, Houston, TX 77030 USA

[2] Ontario Canc Inst, Div Signaling Biol, Toronto, ON M4X 1K9, Canada

[3] Weizmann Inst Sci, Dept Regulat Biol, IL-76100 Rehovot, Israel

[4] Beatson Inst Canc Res, Integrin Cell Biol Lab, Glasgow G61 1BD, Lanark, Scotland

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2009年 / 119卷 / 08期

关键词：

ALPHA-5-BETA-1; INTEGRIN; MIGRATION; GENE;

D O I：

10.1172/JCI40256

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Aberrant endocytosis, vesicle targeting, and receptor recycling represent emerging hallmarks of cancer. In this issue of the JCI, Zhang and colleagues demonstrate that RAB-coupling protein (RCP; also known as RAB11FIP1) is a "driver" of the 8p11-12 amplicon in human breast cancer and mouse xenograft models of mammary carcinogenesis (see the related article beginning on page 2171). Their finding that RAB GTPase function enables genomic amplification to confer aggressiveness to mammary tumors adds significantly to the body of evidence supporting pivotal roles for receptor trafficking in the proliferation and metastasis of cancer.

引用

页码：2123 / 2127

页数：5

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