Chemotherapy for falciparum malaria: The armoury, the problems and the prospects

被引:153
作者
Winstanley, PA [1 ]
机构
[1] Univ Liverpool, Dept Therapeut & Pharmacol, Liverpool L69 3GE, Merseyside, England
来源
PARASITOLOGY TODAY | 2000年 / 16卷 / 04期
关键词
D O I
10.1016/S0169-4758(99)01622-1
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
Peter Winstanley here describes the pharmacology and therapeutics of the main drugs used for falciparum malaria in the tropical setting, rather than in the developed world, as an overview for newcomers to the field. He then examines some of the current major problems and prospects for the future.
引用
收藏
页码:146 / 153
页数:8
相关论文
共 68 条
  • [1] ANTIMALARIAL DRUG RESPONSE OF PLASMODIUM-FALCIPARUM FROM ZARIA, NIGERIA
    ADAGU, IS
    WARHURST, DC
    OGALA, WN
    ABDUAGUYE, I
    AUDU, LI
    BAMGBOLA, FO
    OVWIGHO, UB
    [J]. TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1995, 89 (04) : 422 - 425
  • [2] Adagu IS, 1997, ANN TROP MED PARASIT, V91, pS107, DOI 10.1080/00034989761391
  • [3] Albert DA, 1998, JCR-J CLIN RHEUMATOL, V4, P57, DOI 10.1097/00124743-199804000-00004
  • [4] Chlorproguanil-dapsone: Effective treatment for uncomplicated falciparum malaria
    Amukoye, E
    Winstanley, PA
    Watkins, WM
    Snow, RW
    Hatcher, J
    Mosobo, M
    Ngumbao, E
    Lowe, B
    Ton, M
    Minyiri, G
    Marsh, K
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (10) : 2261 - 2264
  • [5] Malarone-donation programme in Africa
    Bloland, PB
    Kazembe, PN
    Watkins, WM
    Doumbo, OK
    Nwanyanwu, OC
    Ruebush, TK
    [J]. LANCET, 1997, 350 (9091) : 1624 - 1625
  • [6] A comparison of the phenomenology and genetics of multidrug resistance in cancer cells and quinoline resistance in Plasmodium falciparum
    Bray, PG
    Ward, SA
    [J]. PHARMACOLOGY & THERAPEUTICS, 1998, 77 (01) : 1 - 28
  • [7] Cellular uptake of chloroquine is dependent on binding to ferriprotoporphyrin IX and is independent of NHE activity in Plasmodium falciparum
    Bray, PG
    Janneh, O
    Raynes, KJ
    Mungthin, M
    Ginsburg, H
    Ward, SA
    [J]. JOURNAL OF CELL BIOLOGY, 1999, 145 (02) : 363 - 376
  • [8] Brewer T G, 1998, Med Trop (Mars), V58, P22
  • [9] First-time-in-humans safety and pharmacokinetics of WR 238605, a new antimalarial
    Brueckner, RP
    Lasseter, KC
    Lin, ET
    Schuster, BG
    [J]. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1998, 58 (05) : 645 - 649
  • [10] Antimalarial activity of molecules interfering with Plasmodium falciparum phospholipid metabolism. Structure-activity relationship analysis
    Calas, M
    Cordina, G
    Bompart, J
    BenBari, M
    Jei, T
    Ancelin, ML
    Vial, H
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1997, 40 (22) : 3557 - 3566